Iron deficiency anemia is highly prevalent among human immunodeficiency virus-infected and uninfected infants in Uganda

Dana TOTIN; Christopher NDUGWA; Francis MMIRO; Robert T PERRY; J. Brooks JACKSON; Richard D SEMBA

doi:10.1093/jn/132.3.423

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Iron deficiency anemia is highly prevalent among human immunodeficiency virus-infected and uninfected infants in Uganda

Journal article

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Iron deficiency anemia is highly prevalent among human immunodeficiency virus-infected and uninfected infants in Uganda

Dana TOTIN, Christopher NDUGWA, Francis MMIRO, Robert T PERRY, J. Brooks JACKSON and Richard D SEMBA

The Journal of nutrition, Vol.132(3), pp.423-429

2002

DOI: 10.1093/jn/132.3.423

PMID: 11880566

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Abstract

Although anemia is a common finding among human immunodeficiency (HIV)-infected infants in sub-Saharan Africa, the factors contributing to the pathogenesis of anemia have not been well characterized. We sought to characterize the relative contribution of iron deficiency and chronic disease to the anemia among infants. Hemoglobin, ferritin, erythropoietin, tumor necrosis factor-alpha (TNF-alpha), neopterin, CD4(+) lymphocyte count and plasma HIV load were measured in 165 HIV-infected and 39 uninfected 9-mo-old infants seen in an outpatient pediatric clinic in Kampala, Uganda. Among HIV-infected and uninfected infants, the prevalence of anemia (hemoglobin < 110 g/L) was 90.9 and 76.9%, respectively (P = 0.015), and the prevalence of iron deficiency anemia (hemoglobin < 110 g/L and ferritin < 12 microg/L) was 44.3 and 45.4%, respectively (P = 0.92). The relatively higher prevalence of anemia among HIV-infected infants was attributed to the anemia of chronic disease. Among infants with and without iron deficiency, the fitted regression line was log(10) plasma erythropoietin = 2.86 - 0.016.hemoglobin, and log(10) plasma erythropoietin = 4.11 - 0.028.hemoglobin, respectively, with a difference in the slope of the regression lines between log(10) erythropoietin and hemoglobin among infants with and without iron deficiency (P = 0.049). Infants in Uganda have an extremely high prevalence of anemia, and nearly half of the anemia is due to iron deficiency. The erythropoietin response to anemia appears to be upregulated among infants with iron deficiency.

Biological and medical sciences

Details

Title: Subtitle: Iron deficiency anemia is highly prevalent among human immunodeficiency virus-infected and uninfected infants in Uganda
Creators: Dana TOTIN - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Christopher NDUGWA - Department of Paediatrics and Child Health, Makerere University School of Medicine, Kampala, Uganda
Francis MMIRO - Department of Obstetrics and Gynaecology, Makerere University School of Medicine, Kampala, Uganda
Robert T PERRY - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
J. Brooks JACKSON - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Richard D SEMBA - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Resource Type: Journal article
Publication Details: The Journal of nutrition, Vol.132(3), pp.423-429
DOI: 10.1093/jn/132.3.423
PMID: 11880566
NLM abbreviation: J Nutr
ISSN: 0022-3166
eISSN: 1541-6100
Publisher: American Society for Nutritional Sciences; Bethesda, MD
Language: English
Date published: 2002
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047880202771

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