Journal article
Iron in chronic brain disorders: Imaging and neurotherapeutic implications
Neurotherapeutics, Vol.4(3), pp.371-386
07/01/2007
DOI: 10.1016/j.nurt.2007.05.006
PMCID: PMC1963417
PMID: 17599703
Abstract
Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.
In vitro
studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive
in vivo
iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.
Details
- Title: Subtitle
- Iron in chronic brain disorders: Imaging and neurotherapeutic implications
- Creators
- James Stankiewicz - Brigham and Women's HospitalS. Scott Panter - University of California, San FranciscoMohit Neema - Brigham and Women's HospitalAshish Arora - Brigham and Women's HospitalCourtney E. Batt - Brigham and Women's HospitalRohit Bakshi - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- Neurotherapeutics, Vol.4(3), pp.371-386
- Publisher
- Springer-Verlag
- DOI
- 10.1016/j.nurt.2007.05.006
- PMID
- 17599703
- PMCID
- PMC1963417
- ISSN
- 1933-7213
- eISSN
- 1878-7479
- Language
- English
- Date published
- 07/01/2007
- Academic Unit
- Psychiatry
- Record Identifier
- 9984627298402771
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