Journal article
Iron-mediated cardiovascular injury
Vascular medicine (London, England), Vol.4(2), pp.93-99
1999
DOI: 10.1177/1358836X9900400207
PMID: 10406456
Abstract
Iron is an essential element for normal cellular function and general health. However, iron may play a pathologic role in certain cardiac conditions including reperfusion injury, hemochromatosis, b-thalassemia and coronary atherosclerosis. It also may play a role in injury due to anthracycline cardiotoxicity. Removal of iron via phlebotomy for hemochromatosis and chelation therapy for b-thalassemia are proven treatments. Cell culture, and isolated organ and animal studies suggest that depleting iron stores may prevent reperfusion injury, restenosis and even atherogenesis. This article will review mechanisms by which iron overload states and normal iron stores contribute to cardiovascular pathophysiology and the accumulating evidence that iron chelation may prevent restenosis and atherogenesis.
Details
- Title: Subtitle
- Iron-mediated cardiovascular injury
- Creators
- Lawrence D Horwitz - University of Colorado HealthEli A Rosenthal - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- Vascular medicine (London, England), Vol.4(2), pp.93-99
- DOI
- 10.1177/1358836X9900400207
- PMID
- 10406456
- NLM abbreviation
- Vasc Med
- ISSN
- 1358-863X
- eISSN
- 1477-0377
- Language
- English
- Date published
- 1999
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656595902771
Metrics
6 Record Views