Iron status in toddlerhood predicts sensitivity to psychostimulants in children

Catharyn A Turner; Diqiong Xie; Bridget M Zimmerman; Chadi A Calarge

doi:10.1177/1087054710385067

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Iron status in toddlerhood predicts sensitivity to psychostimulants in children

Journal article

Peer reviewed

Iron status in toddlerhood predicts sensitivity to psychostimulants in children

Catharyn A Turner, Diqiong Xie, Bridget M Zimmerman and Chadi A Calarge

Journal of attention disorders, Vol.16(4), pp.295-303

05/2012

DOI: 10.1177/1087054710385067

PMCID: PMC3556512

PMID: 20978274

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Abstract

Iron deficiency is associated with impaired dopaminergic signaling and externalizing behavior. The authors examine, whether iron stores in toddlerhood influence later response to psychostimulants. Youth participating in a study monitoring the long-term safety of risperidone were included in this analysis if they had received psychostimulant monotherapy for at least 3 weeks and had a complete blood count obtained before psychostimulant treatment. Sensitivity to psychostimulants was defined based on the weight-adjusted dose during the 1st year of treatment. Regression analysis examined whether the hematological tests based on the characteristics of red blood cells were associated with sensitivity to psychostimulants. A total of 29 participants (93% men; 76% Whites), primarily with ADHD (93%), comprised the current sample. The hematological tests were obtained, on average, 3 years before the initiation of psychostimulants monotherapy that occurred at 5.8 years of age and continued for a median of 0.85 years, at an average daily dose of 0.98 mg/kg (SD = 0.38) in methylphenidate equivalent. Compared with those who were poorly sensitive to psychostimulants, after adjusting for age, mean corpuscular volume was significantly higher in the highly and moderately psychostimulants sensitive groups. If replicated, these findings suggest that more attention should be paid to optimizing body iron in early childhood.

Humans

Child, Preschool

Infant

Male

Treatment Outcome

Attention Deficit Disorder with Hyperactivity - drug therapy

Anemia, Iron-Deficiency - blood

Central Nervous System Stimulants - therapeutic use

Risperidone - therapeutic use

Antipsychotic Agents - therapeutic use

Methylphenidate - therapeutic use

Female

Child

Details

Title: Subtitle: Iron status in toddlerhood predicts sensitivity to psychostimulants in children
Creators: Catharyn A Turner - University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Diqiong Xie
Bridget M Zimmerman
Chadi A Calarge
Resource Type: Journal article
Publication Details: Journal of attention disorders, Vol.16(4), pp.295-303
DOI: 10.1177/1087054710385067
PMID: 20978274
PMCID: PMC3556512
NLM abbreviation: J Atten Disord
ISSN: 1087-0547
eISSN: 1557-1246
Publisher: United States
Grant note: R21 MH080968 / NIMH NIH HHS RR024979 / NCRR NIH HHS UL1 RR024979 / NCRR NIH HHS K23 MH085005 / NIMH NIH HHS R21MH080968 / NIMH NIH HHS K23MH085005 / NIMH NIH HHS
Language: English
Date published: 05/2012
Academic Unit: Psychiatry; Biostatistics
Record Identifier: 9983997333602771

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