Journal article
Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer
Antioxidants, Vol.10(9), p.1458
09/14/2021
DOI: 10.3390/antiox10091458
PMCID: PMC8465902
PMID: 34573089
Abstract
Cancer cells preferentially accumulate iron (Fe) relative to non-malignant cells; however, the underlying rationale remains elusive. Iron–sulfur (Fe–S) clusters are critical cofactors that aid in a wide variety of cellular functions (e.g., DNA metabolism and electron transport). In this article, we theorize that a differential need for Fe–S biogenesis in tumor versus non-malignant cells underlies the Fe-dependent cell growth demand of cancer cells to promote cell division and survival by promoting genomic stability via Fe–S containing DNA metabolic enzymes. In this review, we outline the complex Fe–S biogenesis process and its potential upregulation in cancer. We also discuss three therapeutic strategies to target Fe–S biogenesis: (i) redox manipulation, (ii) Fe chelation, and (iii) Fe mimicry.
Details
- Title: Subtitle
- Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer
- Creators
- Michael S. Petronek - University of IowaDouglas R. Spitz - University of IowaBryan G. Allen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Antioxidants, Vol.10(9), p.1458
- DOI
- 10.3390/antiox10091458
- PMID
- 34573089
- PMCID
- PMC8465902
- NLM abbreviation
- Antioxidants (Basel)
- ISSN
- 2076-3921
- eISSN
- 2076-3921
- Publisher
- MDPI
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: T32 CA078586, P01 CA217797, R01 CA169046, P01 CA244091, P30 CA086862; DOI: 10.13039/100001634, name: Gateway for Cancer Research, award: G-17-1500
- Language
- English
- Date published
- 09/14/2021
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984312962102771
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