Journal article
Is Bone a Target-Tissue for the Nervous System?: New Advances on the Understanding of Their Interactions
The Iowa orthopaedic journal, Vol.20, pp.49-58
2000
PMCID: PMC1888751
PMID: 10934625
Appears in Diamond Open Access
Abstract
Bone cells respond in specific ways to various hormones and growth factors, but the biology of skeletal innervation and its physiologic significance in bone metabolism is poorly understood. With the introduction of immunohistochemical staining techniques and new molecular biology tools, the knowledge in this field has significantly improved. In this review, we update current understanding of the effects of neuropeptides on bone metabolism, specifically vasoactive intestinal peptide (VIP) and calcitonin-gene related peptide (CGRP). In addition, new information concerning the role of growth factors, such as neurotrophins, is also discussed. There is strong evidence to suggest that bone can be a target of the nervous system. Further investigations in this field will allow us to answer questions related to pre-natal development, bone growth, fracture healing, osteoporosis, osteoarthritis or neoplasias of mesoderm origin.
Details
- Title: Subtitle
- Is Bone a Target-Tissue for the Nervous System?: New Advances on the Understanding of Their Interactions
- Creators
- José M García-Castellano - Departamento de Morfología, Facultad de Medicina, Universidad de Las Palmas de Gran Canaria, SpainPilar Díaz-Herrera - Departamento de Morfología, Facultad de Medicina, Universidad de Las Palmas de Gran Canaria, SpainJosé A Morcuende - Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- The Iowa orthopaedic journal, Vol.20, pp.49-58
- Publisher
- Dept. of Orthopaedics, The University of Iowa; United States
- PMID
- 10934625
- PMCID
- PMC1888751
- ISSN
- 1541-5457
- eISSN
- 1555-1377
- Language
- English
- Date published
- 2000
- Academic Unit
- Stead Family Department of Pediatrics; Orthopedics and Rehabilitation
- Record Identifier
- 9984040221402771
Metrics
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