Journal article
Is CaMKII a link between inflammation and hypertrophy in heart?
Journal of molecular medicine (Berlin, Germany), Vol.89(6), pp.537-543
06/2011
DOI: 10.1007/s00109-011-0727-5
PMCID: PMC3731449
PMID: 21279501
Abstract
Myocardial infarction is a major cause of morbidity and mortality in the developing and developed world. Although current interventions have been successful in prolonging life, they are inadequate because mortality is still high among MI patients. The multifunctional Ca2+/calmodulin-dependent protein kinase (CaMKII) plays a key role in the structure and contractility of the myocardium. CaMKII activity is increased in MI hearts and CaMKII promotes cardiac hypertrophy and inflammation, processes consistently activated by myocardial injury. Hypertrophy and inflammation are also related to neurohumoral and redox signaling which uncouple CaMKII activation from Ca2+/calmodulin dependence. Thus, CaMKII may act as a nodal point for integrating hypertrophic and inflammatory signaling in myocardium.
Details
- Title: Subtitle
- Is CaMKII a link between inflammation and hypertrophy in heart?
- Creators
- Madhu Singh - Departments of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA 52242 USAMark Anderson - Departments of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Journal of molecular medicine (Berlin, Germany), Vol.89(6), pp.537-543
- DOI
- 10.1007/s00109-011-0727-5
- PMID
- 21279501
- PMCID
- PMC3731449
- NLM abbreviation
- J Mol Med (Berl)
- ISSN
- 0946-2716
- eISSN
- 1432-1440
- Publisher
- Springer-Verlag
- Language
- English
- Date published
- 06/2011
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094520602771
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