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Is Family History of Depression a Risk Factor for Poststroke Depression? Meta-Analysis
Journal article   Peer reviewed

Is Family History of Depression a Risk Factor for Poststroke Depression? Meta-Analysis

Veselin T Tenev, Robert G Robinson and Ricardo E Jorge
The American journal of geriatric psychiatry, Vol.17(4), pp.276-280
04/2009
DOI: 10.1097/JGP.0b013e3181953b6e
PMCID: PMC2696692
PMID: 19307856
url
http://doi.org/10.1097/JGP.0b013e3181953b6eView
Open Access

Abstract

To determine whether family history of psychiatric disorder constitutes a risk factor for the development of poststroke depression. A meta-analysis setting: patients examined for depression following stroke seen in acute care, rehabilitation hospital, or outpatient care settings. All patients who were reported in the world's literature in English language publications in which information was provided about the existence or not of poststroke depression and the presence or absence of a family history of psychiatric disorder. The frequency of family history of psychiatric disorder was determined for each study as well as the relationship of family history to the presence of poststroke depression. Based on data obtained from 903 patients with stroke, the fixed model analysis found a risk ratio of 1.51 and the random model a risk ratio of 1.46 for the existence of poststroke depression if there is a positive family history of psychiatric disorder compared with a negative family history. The existence of a positive family history of psychiatric disorder constitutes a risk factor for development of poststroke depression. The role of family history in poststroke depression, however, appears to be substantially lower than among elderly depressed patients without evidence of vascular disease.
 Poststroke depression risk factors family history

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