Journal article
Is Homoarginine a Protective Cardiovascular Risk Factor?
Arteriosclerosis, thrombosis, and vascular biology, Vol.39(5), pp.869-875
05/2019
DOI: 10.1161/ATVBAHA.118.312218
PMID: 30866658
Abstract
A series of recent epidemiological studies have implicated the endogenous nonproteinogenic amino acid l-homoarginine as a novel candidate cardiovascular risk factor. The association between homoarginine levels and the risk of adverse cardiovascular outcomes is inverse (ie, high cardiovascular risk is predicted by low rather than high homoarginine levels), which makes it plausible to normalize systemic homoarginine levels via oral supplementation. The emergence of homoarginine as a potentially treatable protective cardiovascular risk factor has generated a wave of hope in the field of cardiovascular prevention. Herein, we review the biochemistry, physiology, and metabolism of homoarginine, summarize the strengths and weaknesses of the epidemiological evidence linking homoarginine to cardiovascular disease and its potential protective cardiovascular effects, and identify priorities for future research needed to define the clinical utility of homoarginine as a prognostic factor and therapeutic target in cardiovascular disease.
Details
- Title: Subtitle
- Is Homoarginine a Protective Cardiovascular Risk Factor?
- Creators
- Ekaterina S Karetnikova - From the Department of Physiology, Saint-Petersburg State University, Russia (E.S.K., A.G.M.)Natalia Jarzebska - University Hospital Carl Gustav CarusAlexander G Markov - From the Department of Physiology, Saint-Petersburg State University, Russia (E.S.K., A.G.M.)Norbert Weiss - University Hospital Carl Gustav CarusSteven R Lentz - University of IowaRoman N Rodionov - Technische Universität Dresden
- Resource Type
- Journal article
- Publication Details
- Arteriosclerosis, thrombosis, and vascular biology, Vol.39(5), pp.869-875
- DOI
- 10.1161/ATVBAHA.118.312218
- PMID
- 30866658
- NLM abbreviation
- Arterioscler Thromb Vasc Biol
- ISSN
- 1079-5642
- eISSN
- 1524-4636
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359564902771
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