Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study

Joseph J. Fantony; Lauren E. Howard; Ilona Csizmadi; Andrew J. Armstrong; Amy L. Lark; Colette Galet; William J. Aronson; Stephen J. Freedland

doi:10.2217/bmm-2017-0322

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Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study

Journal article

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Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study

Joseph J. Fantony, Lauren E. Howard, Ilona Csizmadi, Andrew J. Armstrong, Amy L. Lark, Colette Galet, William J. Aronson and Stephen J. Freedland

Biomarkers in medicine, Vol.12(7), pp.727-736

07/01/2018

DOI: 10.2217/bmm-2017-0322

PMID: 29902938

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Abstract

Aim: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). Methods: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. Results: Ki67 was associated with more recent surgery year (p < 0.001), positive margins (p = 0.001) and extracapsular extension (p < 0.001). In center-stratified analyses, the adjusted HR for Ki67 expression and BCR approached statistical significance for west LA (HR: 1.54; p = 0.06), but not Durham (HR: 1.10; p = 0.74). Conclusion: This multi-institutional ` real-world' study provides limited evidence for the prognostic role of Ki67 in predicting outcome after RP.

Life Sciences & Biomedicine

Medicine, Research & Experimental

Research & Experimental Medicine

Science & Technology

Details

Title: Subtitle: Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study
Creators: Joseph J. Fantony - Duke University
Lauren E. Howard - Durham VA Medical Center
Ilona Csizmadi - Cedars-Sinai Medical Center
Andrew J. Armstrong - Duke University
Amy L. Lark - Duke University Hospital
Colette Galet - University of Iowa
William J. Aronson - University of California, Los Angeles
Stephen J. Freedland - Durham VA Medical Center
Resource Type: Journal article
Publication Details: Biomarkers in medicine, Vol.12(7), pp.727-736
DOI: 10.2217/bmm-2017-0322
PMID: 29902938
NLM abbreviation: Biomark Med
ISSN: 1752-0363
eISSN: 1752-0371
Publisher: Future Medicine Ltd
Number of pages: 10
Grant note: K24 CA160653 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P50CA09231 / NIH/NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
Language: English
Date published: 07/01/2018
Academic Unit: Injury Prevention Research Center; University of Iowa Health Care
Record Identifier: 9985137927002771

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