Journal article
Is Pelvic Floor Muscle Tenderness a Distinct Urologic Chronic Pelvic Pain Syndrome Phenotype? Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Symptom Pattern Study
The Journal of urology, Vol.208(2), pp.341-349
08/01/2022
DOI: 10.1097/JU.0000000000002679
PMCID: PMC10123541
PMID: 35344391
Abstract
Purpose: Of women with interstitial cystitis/bladder pain syndrome and men with chronic prostatitis/chronic pelvic pain syndrome 85% have concomitant pelvic floor muscle tenderness (PFT). The significance of this finding is incompletely understood. This study examines PFT among participants in the MAPP (Multidisciplinary Approach to the Study of Chronic Pelvic Pain) Research Network and its relationship with urologic chronic pelvic pain syndrome (UCPPS) symptom severity in order to determine whether this is a phenotypic predictor in UCPPS.
Materials and Methods: Participants in the MAPP Network Symptom Patterns Study underwent a standardized pelvic examination (PEX). Trained examiners palpated 6 locations evaluating the pelvic musculature for PFT. Participants were assigned a 0 to 6 PEX score based on the number of areas with tenderness on PEX. Using regression tree models, PEX scores were divided into low (0, 1), mid (2, 3, 4, 5) and high (6). The relationship between PFT and UCPPS symptoms was examined using several validated questionnaires.
Results: The study cohort consisted of 562 UCCPS participants (375 females and 187 males) and 69 controls. Diagnoses included interstitial cystitis/bladder pain syndrome (397), chronic prostatitis/chronic pelvic pain syndrome (122), both (34) or no diagnosis (9). Of UCPPS participants 81% had PFT on PEX compared to 9% of controls: 107 (19%) low, 312 (56%) mid and 143 (25%) high. Participants with higher PFT scores had more severe disease burden (worse pelvic pain and urinary symptoms), worse quality of life and more widespread distribution of nonpelvic pain.
Conclusions: UCPPS patients with more widespread PFT have severe pain and urinary symptoms, worse quality of life and a more centralized pain phenotype.
Details
- Title: Subtitle
- Is Pelvic Floor Muscle Tenderness a Distinct Urologic Chronic Pelvic Pain Syndrome Phenotype? Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Symptom Pattern Study
- Creators
- Priyanka Gupta - University of Michigan–Ann ArborRobert Gallop - University of PennsylvaniaTheresa Spitznagle - Washington University in St. LouisHenry Lai - Washington University in St. LouisFrank Tu - Northwestern UniversityJohn N. Krieger - University of WashingtonJ. Quentin Clemens - University of Michigan–Ann ArborCatherine S. Bradley - University of IowaClaire Yang - University of WashingtonSiobhan Sutcliffe - Washington University in St. Louis School of MedicineRobert Moldwin - Northwell HealthKarl Kreder - University of IowaJason Kutch - University of Southern CaliforniaLarissa Rodriguez - University of Southern California
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.208(2), pp.341-349
- DOI
- 10.1097/JU.0000000000002679
- PMID
- 35344391
- PMCID
- PMC10123541
- NLM abbreviation
- J Urol
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Grant note
- DK82370; DK82342; DK82315; DK82344; DK82325; DK82345; DK82333; DK82316; DK121724 / National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 08/01/2022
- Academic Unit
- Epidemiology; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984315569602771
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