Journal article
Is age-related macular degeneration a microvascular disease?
Advances in experimental medicine and biology, Vol.801, pp.283-289
2014
DOI: 10.1007/978-1-4614-3209-8_36
PMCID: PMC8412173
PMID: 24664709
Abstract
Age-related macular degeneration (AMD) is a common, degenerative disease of the central retina affecting millions of elderly in the USA alone and many more worldwide. A better understanding of the pathophysiology of AMD will be essential for developing new treatments. In this review, we discuss the potential impact of complement complex deposition at the choriocapillaris of aging eyes and the relationship between choriocapillaris loss and drusen formation. We further propose a model that integrates genetic and anatomical findings in AMD and suggest the implications of these findings for future therapies.
Details
- Title: Subtitle
- Is age-related macular degeneration a microvascular disease?
- Creators
- Robert F Mullins - Department of Ophthalmology and Visual Sciences, The University of Lowa, 52242, Lowa City, IA, USA, Robert-Mullins@uiowa.eduAditi KhannaDesi P SchooBudd A TuckerElliott H SohnArlene V DrackEdwin M Stone
- Resource Type
- Journal article
- Publication Details
- Advances in experimental medicine and biology, Vol.801, pp.283-289
- DOI
- 10.1007/978-1-4614-3209-8_36
- PMID
- 24664709
- PMCID
- PMC8412173
- NLM abbreviation
- Adv Exp Med Biol
- ISSN
- 0065-2598
- eISSN
- 2214-8019
- Publisher
- United States
- Grant note
- DP2 OD007483 / NIH HHS EY-016822 / NEI NIH HHS EY-017451 / NEI NIH HHS
- Language
- English
- Date published
- 2014
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980093502771
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