Journal article
Is clinical effect of autologous conditioned serum in spontaneously occurring equine articular lameness related to ACS cytokine profile?
BMC veterinary research, Vol.16(1), pp.181-181
06/08/2020
DOI: 10.1186/s12917-020-02391-7
PMCID: PMC7278142
PMID: 32513154
Abstract
Background Biologic' therapies, such as autologous conditioned serum (ACS), are gaining popularity in treating orthopaedic conditions in equine veterinary medicine. Evidence is scarce regarding ACS constituents, and large inter-individual differences in cytokine and growth factor content have been demonstrated. The objective of the current study was to investigate the potential association between cytokine and growth factor content of ACS and clinical effect in harness racehorses with spontaneously occurring low-grade articular lameness. Horses received 3 intra-articular injections of ACS administered at approximately 2-week intervals. Lameness evaluation consisting of a trot-up with subsequent flexions tests was performed at inclusion and approximately 2 weeks after the last treatment (re-evaluation); horses were classified as responders when there was no detectable lameness on trot-up and a minimum of 50% reduction in flexion test scores at re-evaluation. Association between clinical outcome (responders vs. non-responders) and age, lameness grades at inclusion (both initial trot-up and after flexion tests), treatment interval, follow-up time and the ACS content of IL-1Ra, IGF-1 and TGF-beta was determined by regression modelling. Results Outcome analysis was available for 19 of 20 included horses; 11 responded to treatment whereas 8 did not. There was considerable inter-individual variability in cytokine/growth factor content of ACS, and in the majority of the horses, the level of IL-10, IL-1 beta and TNF-alpha was below the detection limit. In the final multivariate logistic regression model, ACS content of IGF-1 and IL-1Ra was significantly associated with clinical response (P = 0.01 and P = 0.03, respectively). No association with clinical response was found for the other tested variables. Conclusions The therapeutic benefit of ACS may be related to higher levels of IL-1Ra and IGF-1. Our study corroborates previous findings of considerable inter-individual variability of cytokine- and growth factor content in ACS.
Details
- Title: Subtitle
- Is clinical effect of autologous conditioned serum in spontaneously occurring equine articular lameness related to ACS cytokine profile?
- Creators
- Patrick Marques-Smith - Norwegian University of Life SciencesAnne S. Kallerud - Norwegian University of Life SciencesGrethe M. Johansen - Norwegian University of Life SciencesPreben Boysen - Norwegian University of Life SciencesAnna M. Jacobsen - Norwegian University of Life SciencesKaroline M. Reitan - Norwegian University of Life SciencesMia M. Henriksen - Norwegian University of Life SciencesMaria Lofgren - Swedish University of Agricultural SciencesCathrine T. Fjordbakk - Norwegian University of Life Sciences
- Resource Type
- Journal article
- Publication Details
- BMC veterinary research, Vol.16(1), pp.181-181
- DOI
- 10.1186/s12917-020-02391-7
- PMID
- 32513154
- PMCID
- PMC7278142
- NLM abbreviation
- BMC Vet Res
- ISSN
- 1746-6148
- eISSN
- 1746-6148
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- H-16-47-182 / Norwegian Research Council; Research Council of Norway; European Commission Swedish/Norwegian Foundation for Equine Research
- Language
- English
- Date published
- 06/08/2020
- Academic Unit
- Nursing
- Record Identifier
- 9984370640502771
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