Is gastroschisis associated with county-level socio-environmental quality during pregnancy?

Alison K Krajewski; Achal Patel; Christine L Gray; Lynne C Messer; Corinna Y Keeler; Peter H Langlois; Jennita Reefhuis; Suzanne M Gilboa; Martha M Werler; Gary M Shaw; Suzan L Carmichael; Wendy N Nembhard; Tabassum Z Insaf; Marcia L Feldkamp; Kristin M Conway; Danelle T Lobdell; Tania A Desrosiers; National Birth Defects Prevention Study

doi:10.1002/bdr2.2250

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Is gastroschisis associated with county-level socio-environmental quality during pregnancy?

Journal article

Open access

Peer reviewed

Is gastroschisis associated with county-level socio-environmental quality during pregnancy?

Alison K Krajewski, Achal Patel, Christine L Gray, Lynne C Messer, Corinna Y Keeler, Peter H Langlois, Jennita Reefhuis, Suzanne M Gilboa, Martha M Werler, Gary M Shaw, …

Birth defects research, Vol.115(18), pp.1758-1769

11/01/2023

DOI: 10.1002/bdr2.2250

PMCID: PMC10878499

PMID: 37772934

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Abstract

Gastroschisis prevalence more than doubled between 1995 and 2012. While there are individual-level risk factors (e.g., young maternal age, low body mass index), the impact of environmental exposures is not well understood. We used the U.S. Environmental Protection Agency's Environmental Quality Index (EQI) as a county-level estimate of cumulative environmental exposures for five domains (air, water, land, sociodemographic, and built) and overall from 2006 to 2010. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were estimated from logistic regression models between EQI tertiles (better environmental quality (reference); mid; poorer) and gastroschisis in the National Birth Defects Prevention Study from births delivered between 2006 and 2011. Our analysis included 594 cases with gastroschisis and 4105 infants without a birth defect (controls). Overall EQI was modestly associated with gastroschisis (aOR [95% CI]: 1.29 [0.98, 1.71]) for maternal residence in counties with poorer environmental quality, compared to the reference (better environmental quality). Within domain-specific indices, only the sociodemographic domain (aOR: 1.51 [0.99, 2.29]) was modestly associated with gastroschisis, when comparing poorer to better environmental quality. Future work could elucidate pathway(s) by which components of the sociodemographic domain or possibly related psychosocial factors like chronic stress potentially contribute to risk of gastroschisis.

Environmental Exposure - adverse effects

Female

Gastroschisis - epidemiology

Gastroschisis - etiology

Humans

Infant

Maternal Age

Odds Ratio

Pregnancy

Prevalence

Details

Title: Subtitle: Is gastroschisis associated with county-level socio-environmental quality during pregnancy?
Creators: Alison K Krajewski - Environmental Protection Agency
Achal Patel - University of North Carolina at Chapel Hill
Christine L Gray - Duke Institute for Health Innovation
Lynne C Messer - OHSU-PSU School of Public Health, Portland, Oregon, USA
Corinna Y Keeler - University of North Carolina at Chapel Hill
Peter H Langlois - Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas School of Public Health-Austin Regional Campus, Austin, Texas, USA
Jennita Reefhuis - Centers for Disease Control and Prevention
Suzanne M Gilboa - National Center on Birth Defects and Developmental Disabilities
Martha M Werler - Boston University
Gary M Shaw - Stanford University
Suzan L Carmichael - Stanford University
Wendy N Nembhard - University of Arkansas for Medical Sciences
Tabassum Z Insaf - New York State Department of Health
Marcia L Feldkamp - University of Utah
Kristin M Conway - University of Iowa
Danelle T Lobdell - Environmental Protection Agency
Tania A Desrosiers - University of North Carolina at Chapel Hill
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research, Vol.115(18), pp.1758-1769
DOI: 10.1002/bdr2.2250
PMID: 37772934
PMCID: PMC10878499
NLM abbreviation: Birth Defects Res
ISSN: 2472-1727
eISSN: 2472-1727
Publisher: Wiley
Grant note: U01 DD001300 / NCBDD CDC HHS U01DD001231 / ACL HHS U01 DD001304 / NCBDD CDC HHS U01 DD001032 / NCBDD CDC HHS CC999999 / Intramural CDC HHS U01 DD001224 / NCBDD CDC HHS U01 DD001227 / NCBDD CDC HHS U01 DD001037 / NCBDD CDC HHS
Language: English
Date published: 11/01/2023
Academic Unit: Epidemiology
Record Identifier: 9984627336902771

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