Journal article
Is local recurrence in bone and soft tissue sarcomas just a local recurrence or does it impact the overall survival, retrospective cohort from a sarcoma referral center
Journal of surgical oncology, Vol.124(8), pp.1536-1543
12/2021
DOI: 10.1002/jso.26663
PMID: 34472103
Abstract
Background and Objectives: Sarcoma local recurrence (LR) is often associated with metastasis, but it is unclear if LR can be a causal event leading to metastasis. We question if LR is best viewed as an independent oncologic event or as a worrisome harbinger threatening a patient's overall survival. Methods: We identified patients with LR and/or metastasis from an ongoing cohort of 629 patients with primary sarcoma and performed a detailed review to assess the timing of metastasis resulting in the following groups: (1) Isolated LR, (2) LR before metastasis, (3) LR within 6 months of metastasis, (4) LR 6–12 months after metastasis, (5) LR >12 months after metastasis, and (6) metastasis at diagnosis. Results: Overall, 43 patients met the inclusion criteria with an LR rate of 7%. Ten patients (2% of the entire cohort, 23% of LR) developed an LR before or within 6 months of metastasis. For patients without systemic disease preceding LR, 3 of 23 soft tissue sarcoma STS (13%) and 7 of 10 bone sarcoma (70%) subsequently developed metastasis (p < 0.01). Conclusion: LR with subsequent metastasis is a rare event. LR appears to be best viewed as a marker of tumor aggressiveness rather than the cause of metastasis and poor survival. LR in bone sarcoma patients should warn providers of a high risk of imminent metastasis.
Details
- Title: Subtitle
- Is local recurrence in bone and soft tissue sarcomas just a local recurrence or does it impact the overall survival, retrospective cohort from a sarcoma referral center
- Creators
- Obada Hasan - University of Iowa Hospitals and ClinicsMomin Nasir - University of IowaMuneeba Jessar - Chandka Medical CollegeMustafa Hashimi - University of IowaQiang An - University of IowaBenjamin J. Miller - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of surgical oncology, Vol.124(8), pp.1536-1543
- DOI
- 10.1002/jso.26663
- PMID
- 34472103
- ISSN
- 0022-4790
- eISSN
- 1096-9098
- Language
- English
- Date published
- 12/2021
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984303981402771
Metrics
20 Record Views