Journal article
Is maternal parity an independent risk factor for birth defects?
Birth defects research. A Clinical and molecular teratology, Vol.94(4), pp.230-236
04/2012
DOI: 10.1002/bdra.22889
PMCID: PMC4476024
PMID: 22371332
Abstract
BACKGROUND
Although associations between maternal parity and birth defects have been observed previously, few studies have focused on the possibility that parity is an independent risk factor for birth defects. We investigated the relation between levels of parity and a range of birth defects, adjusting each defect group for the same covariates.
METHODS
We included infants who had an estimated delivery date between 1997 and 2007 and participated in the National Birth Defects Prevention Study, a multisite case-control study. Cases included infants or fetuses belonging to 38 phenotypes of birth defects (n = 17,908), and controls included infants who were unaffected by a major birth defect (n = 7173). Odds ratios (ORs) were adjusted for 12 covariates using logistic regression.
RESULTS
Compared with primiparous mothers, nulliparous mothers were more likely to have infants with amniotic band sequence, hydrocephaly, esophageal atresia, hypospadias, limb reduction deficiencies, diaphragmatic hernia, omphalocele, gastroschisis, tetralogy of Fallot, and septal cardiac defects, with significant ORs (1.2 to 2.3). Compared with primiparous mothers, multiparous mothers had a significantly increased risk of omphalocele, with an OR of 1.5, but had significantly decreased risk of hypospadias and limb reduction deficiencies, with ORs of 0.77 and 0.77.
CONCLUSIONS
Nulliparity was associated with an increased risk of specific phenotypes of birth defects. Most of the phenotypes associated with nulliparity in this study were consistent with those identified by previous studies. Research into biologic or environmental factors that are associated with nulliparity may be helpful in explaining some or all of these associations.
Details
- Title: Subtitle
- Is maternal parity an independent risk factor for birth defects?
- Creators
- Hao T Duong - The University of Texas, Houston Health Science Center, School of Public Health, Houston, TexasAdrienne T Hoyt - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasSuzan L Carmichael - Stanford University School of Medicine, Stanford, CaliforniaSuzanne M Gilboa - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaMark A Canfield - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasAmy Case - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasMelanie L McNeese - The University of Texas, Houston Health Science Center, School of Public Health, Houston, TexasDorothy Kim Waller - The University of Texas, Houston Health Science Center, School of Public Health, Houston, TexasNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth defects research. A Clinical and molecular teratology, Vol.94(4), pp.230-236
- DOI
- 10.1002/bdra.22889
- PMID
- 22371332
- PMCID
- PMC4476024
- NLM abbreviation
- Birth Defects Res A Clin Mol Teratol
- ISSN
- 1542-0752
- eISSN
- 1542-0760
- Publisher
- Wiley
- Number of pages
- 7
- Language
- English
- Date published
- 04/2012
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214812002771
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