Journal article
Is muscle strength in a painful limb affected by knee pain status of the contralateral limb? - Data from the Osteoarthritis Initiative
Annals of anatomy, Vol.221, pp.68-75
01/01/2019
DOI: 10.1016/j.aanat.2018.08.003
PMID: 30240905
Abstract
Contralateral knee pain has been suggested to be associated with muscle weakness in a pain-free knee, potentially through a mechanism of central nervous inhibition. Whether contralateral knee pain also affects muscle strength in a painful knee, however, is unknown. Here we study the extent to which isometric muscle strength differs between matched painful limbs of people with unilateral knee pain vs. matched painful limbs people with bilateral knee pain. To that end, 163 participants with unilateral knee pain were identified from the Osteoarthritis Initiative. Unilaterally painful (UP) limbs were defined as having numerical rating scale (NRS) >= 4/10, infrequent/frequent pain in the painful limb, while contralateral pain-free limbs were defined by NRS = 0-1, no/infrequent pain and Western Ontario and McMaster Universities Arthritis Index (WOMAC) <= 1. The comparator group were matched bilaterally painful (BP) limbs. Maximum isometric muscle strength (N) was compared between 1:1 matched BP and UP limbs. Extensor strength was found to be lower in BP limbs than in UP limbs, (-2.9%; p = 0.39) but this difference was not statistically significant. Extensor strength was significantly lower in the UP vs. contralateral pain free limbs (-6.2%; p < 0.001). No differences were observed between BP and contralateral painful limbs (0.6%; p = 0.87). In conclusion, the current results identify a slight reduction of maximum knee extensor strength in a painful limb, when the contralateral knee is also painful. In contrast to pain-free limbs, this effect did not reach statistical significance, but the overall findings support the concept of central nervous inhibition of muscle strength by contralateral knee pain. (C) 2018 Elsevier GmbH. All rights reserved.
Details
- Title: Subtitle
- Is muscle strength in a painful limb affected by knee pain status of the contralateral limb? - Data from the Osteoarthritis Initiative
- Creators
- Eva Steidle-Kloc - Paracelsus Medical UniversityKaitlin Rabe - University of KansasFelix Eckstein - Paracelsus Medical UniversityWolfgang Wirth - Paracelsus Medical UniversityNatalie A. Glass - University of IowaNeil A. Segal - University of Kansas
- Resource Type
- Journal article
- Publication Details
- Annals of anatomy, Vol.221, pp.68-75
- Publisher
- Elsevier
- DOI
- 10.1016/j.aanat.2018.08.003
- PMID
- 30240905
- ISSN
- 0940-9602
- eISSN
- 1618-0402
- Number of pages
- 8
- Grant note
- PMU FFF R-14/01/057-STD / Paracelsus Medical University Research Fund Pfizer, Inc.; Pfizer GlaxoSmithKline N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262 / National Institutes of Health, a branch of the Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Novartis Pharmaceuticals Corporation; Novartis Foundation for the National Institutes of Health Merck Research Laboratories; Merck & Company
- Language
- English
- Date published
- 01/01/2019
- Academic Unit
- Epidemiology; Orthopedics and Rehabilitation
- Record Identifier
- 9984548858202771
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