Journal article
Is occipital bending a structural biomarker of risk for depression and sensitivity to treatment?
Journal of clinical neuroscience, Vol.63, pp.55-61
05/01/2019
DOI: 10.1016/j.jocn.2019.02.007
PMID: 30827879
Abstract
Occipital bending (OB) describes asymmetry of the occipital lobes where one lobe wraps across the mid line, and has been associated with the presence of mood disorders. We evaluated the relationship between OB and major depressive disorder (MDD) in a large population of subjects from the International Study to Predict Optimized Treatment in Depression. MDD patients (n = 231) and healthy controls (n = 68) underwent MRI and neuropsychiatric evaluation, including response or remission to antidepressant medication at baseline and at 8 weeks. Cortical thickness, ventricular volumes and regional grey matter volumes were measured. OB was visually assessed and OB angle measured using a semi automated method. Correlations with MDD diagnosis, MRI measures and clinical features were tested. Results demonstrated a greater proportion of rightwards OB in MDD compared to control subjects (p = 0.02). There was no difference in the total prevalence of OB (combined left and rightward bending) between MDD and controls. MDD subjects with right OB had greater cortical thickness in three medial occipital regions (cuneus, lingual gyrus and calcarine sulcus) on the left. Lateral ventricular size was 20% lower bilaterally in right OB MDD subjects compared to non-OB MDD subjects. OB was not associated with severity (HDRS-17). Our data suggest the presence of a strong link between greater rightward occipital bending and MDD. Rightward-OB is associated with greater left medial occipital cortical thickness, and with reduced lateral ventricular size. The cause for greater rightward bending in MDD patients is unclear, however our data suggest a developmental aetiology. (C) 2019 Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- Is occipital bending a structural biomarker of risk for depression and sensitivity to treatment?
- Creators
- Karen Fullard - The Heart Research InstituteJerome J. Maller - The University of SydneyThomas Welton - The University of SydneyMatthew Lyon - The Heart Research InstituteEvian Gordon - Brain Resource CenterStephen H. Koslow - University of MiamiStuart M. Grieve - The University of Sydney
- Resource Type
- Journal article
- Publication Details
- Journal of clinical neuroscience, Vol.63, pp.55-61
- DOI
- 10.1016/j.jocn.2019.02.007
- PMID
- 30827879
- NLM abbreviation
- J Clin Neurosci
- ISSN
- 0967-5868
- eISSN
- 1532-2653
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- Brain Resource Ltd; Total Brain
- Language
- English
- Date published
- 05/01/2019
- Academic Unit
- Radiology
- Record Identifier
- 9984848425002771
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