Is perinatal depression familial?

Kathleen Murphy-Eberenz; Peter P Zandi; Dana March; Raymond R Crowe; William A Scheftner; Madeline Alexander; Melvin G McInnis; William Coryell; Philip Adams; J. Raymond DePaulo; Erin B Miller; Diana H Marta; James B Potash; Jennifer Payne; Douglas F Levinson

doi:10.1016/j.jad.2005.10.006

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Journal article

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Is perinatal depression familial?

Kathleen Murphy-Eberenz, Peter P Zandi, Dana March, Raymond R Crowe, William A Scheftner, Madeline Alexander, Melvin G McInnis, William Coryell, Philip Adams, J. Raymond DePaulo, …

Journal of affective disorders, Vol.90(1), pp.49-55

2006

DOI: 10.1016/j.jad.2005.10.006

PMID: 16337009

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Abstract

While major depressive disorder (MDD) is familial, it is not clear whether distinct familial-genetic factors influence vulnerability to depression during or after pregnancy. Here we examine familial aggregation of perinatal major depression (PND, any episode during pregnancy or the month after childbirth) and the subset of post-partum depression (PPD) in families with multiple cases of recurrent, early-onset MDD from the Genetics of Recurrent Early-Onset Depression dataset. The dataset included 691 childbearing women who could be classified as PND (27.6%) or non-PND (NPND), of whom 328 were members of 148 sibships with two or more PND or NPND women. PND and NPND subjects were compared for differences in putative predictors. Prediction of sibling PND or PPD by the proband's history was examined using logistic regression and general estimating equation methods. PND was associated with fewer episodes and younger current age. Odds ratios for prediction of sibling status were significant for PND (2.28) and PPD (3.96), particularly when current age was under 46 (2.87 and 4.39, respectively). ORs for PPD were not significantly different from those for PND. The OR for PPD (3.52), but not for PND, remained significant after current age was introduced as a covariate, but not when both current age and number of episodes were included in the model. Because detailed data were not collected for all pregnancies, we cannot determine whether current age and number of episodes mediated the observed effects due to recall bias or other factors (cohort effect, number of episodes). A familial component to PND, and particularly PPD, is suggested by the results. However more systematic study is needed to confirm this result. A greater understanding of both genetic and non-genetic familial factors could lead to improved prevention and clinical management.

Postpartum depression

Family study

Major depression

Perinatal depression

Details

Title: Subtitle: Is perinatal depression familial?
Creators: Kathleen Murphy-Eberenz - Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, United States
Peter P Zandi - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, United States
Dana March - Department of Psychiatry, Columbia University, New York, NY, United States
Raymond R Crowe - Department of Psychiatry, University of Iowa School of Medicine, Iowa City, IW, United States
William A Scheftner - Department of Psychiatry, Rush University Medical Center, Chicago, IL, United States
Madeline Alexander - Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, United States
Melvin G McInnis - Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor, MI, United States
William Coryell - Department of Psychiatry, University of Iowa School of Medicine, Iowa City, IW, United States
Philip Adams - Department of Psychiatry, Columbia University, New York, NY, United States
J. Raymond DePaulo - Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States
Erin B Miller - Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States
Diana H Marta - Department of Psychiatry, Rush University Medical Center, Chicago, IL, United States
James B Potash - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, United States
Jennifer Payne - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, United States
Douglas F Levinson - Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, United States
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.90(1), pp.49-55
DOI: 10.1016/j.jad.2005.10.006
PMID: 16337009
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 2006
Academic Unit: Psychiatry
Record Identifier: 9984004080902771

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