Journal article
Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study
Osteoarthritis and cartilage, Vol.25(10), pp.1647-1653
10/2017
DOI: 10.1016/j.joca.2017.05.019
PMCID: PMC5605441
PMID: 28606556
Abstract
To assess the associations of atrophic tibiofemoral osteoarthritis (OA) with progression of radiographic joint space narrowing (JSN) and magnetic resonance imaging (MRI)-defined progression of cartilage damage.
Participants of the Multicenter Osteoarthritis (MOST) Study with available radiographic and MRI assessments at baseline and 30 months were included. The atrophic OA phenotype was defined as Osteoarthritis Research Society International (OARSI) grades 1 or 2 for JSN and grade 0 for osteophytes. Based on MRI, atrophic OA was defined as tibiofemoral (TF) cartilage damage grades ≥3 in at least 2 of 10 subregions with absent or tiny osteophytes in all TF subregions. Progression of JSN and cartilage loss on MRI, was defined as (1) no, (2) slow, and (3) fast progression. Co-variance and logistic regression with generalized estimated equations were performed to assess the association of atrophic knee OA with any progression, compared to non-atrophic OA knees.
A total of 476 knees from 432 participants were included. There were 50 (10.5%) knees with atrophic OA using the radiographic definition, and 16 (3.4%) knees with atrophic OA using MRI definition. Non-atrophic OA knees more commonly exhibited fast progression of JSN and cartilage damage. Logistic regression showed that the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss.
In this sample, the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss compared to the non-atrophic knee OA phenotype.
Details
- Title: Subtitle
- Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study
- Creators
- M.D Crema - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAD.T Felson - Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, USAA Guermazi - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAM.C Nevitt - Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USAJ Niu - Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, USAJ.A Lynch - Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USAM.D Marra - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAJ Torner - University of Iowa, Iowa City, IA, USAC.E Lewis - University of Alabama, Birmingham, AL, USAF.W Roemer - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.25(10), pp.1647-1653
- DOI
- 10.1016/j.joca.2017.05.019
- PMID
- 28606556
- PMCID
- PMC5605441
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: NIH; name: National Institute of Aging, award: U01-AG-18947, U01-AG-18832, U01-AG-19069, U01-AG-18820; DOI: 10.13039/100000002, name: NIH, award: AR47785
- Language
- English
- Date published
- 10/2017
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995048602771
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