Journal article
Is there a role for an endothelium-derived relaxing factor in nociception?
Brain research, Vol.531(1), pp.342-345
1990
DOI: 10.1016/0006-8993(90)90798-G
PMID: 2289134
Abstract
Many of the circulating algesic agents released in response to ischemia produce a profound vasodilatation possibly through the release of an endothelium-derived relaxing factor (EDRF) as well as pain. We report here that intravenously administered
S-nitrosocysteine, a putative EDRF, and not the nitric oxide liberating compound sodium nitroprusside produces significant alterations in nociceptive behavior that are abolished by bilateral vagotomy. These results are consistent with a role for EDRF in peripheral nociceptive mechanisms.
Details
- Title: Subtitle
- Is there a role for an endothelium-derived relaxing factor in nociception?
- Creators
- Stephen T Meller - Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, IA 52242 U.S.AStephen J Lewis - Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, IA 52242 U.S.AJames N Bates - Department of Anesthesiology, College of Medicine, University of Iowa, Iowa City, IA 52242 U.S.AMichael J Brody - Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, IA 52242 U.S.AG.F Gebhart - Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, IA 52242 U.S.A
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.531(1), pp.342-345
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(90)90798-G
- PMID
- 2289134
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1990
- Academic Unit
- Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984006363202771
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