Journal article
Is use of hormone replacement therapy associated with increased detection of human papillomavirus and potential risk of HPV-related genital cancers?
European journal of cancer prevention, Vol.11(3), pp.295-305
2002
DOI: 10.1097/00008469-200206000-00013
PMID: 12131663
Abstract
Oral contraceptives (OC) are a risk factor for female genital cancers and in vivo studies have shown that progestins stimulate human papillomavirus (HPV) gene expression. A similar role for hormone replacement therapy (HRT) has received little evaluation. Cervical/vaginal specimens were obtained to detect HPV from postmenopausal women (n = 429) seeking annual gynaecologic care. HPV was detected in 14% of women and 4.4% had high-risk, oncogenic types. HPV prevalence was similar across current, past and never HRT users. After adjustment for HPV-related risk factors, current and past user status showed no increased viral detection compared with never users. HRT duration also did not elevate risk among current users. However, longer duration (adj. OR 1.5/year, 95% CI 1.0-2.3) and longer latency (adj. OR 1.2/year, 95% CI 0.9-1.7) among past users of oestrogen/progestin regimens were associated with greater risk. Overall use of HRTs was not associated with HPV detection or disease. However, past users of combination HRTs had significantly greater risk of HPV detection with longer HRT duration and latency, similar to OC-HPV findings. The recommendation that postmenopausal women continue HRTs long term may lead to an increased development of HPV-related diseases, of particular concern among those who discontinue HRTs and subsequent gynaecologic care for early cancer detection.
Details
- Title: Subtitle
- Is use of hormone replacement therapy associated with increased detection of human papillomavirus and potential risk of HPV-related genital cancers?
- Creators
- E. M SMITH - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesB. T LEVY - Department of Family Medicine, College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesJ. M RITCHIE - Department of Biostatistics; College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesJ JIA - Department of Biostatistics; College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesD WANG - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesT. H HAUGEN - Veterans Affairs Medical Center, Iowa City, Iowa 52240, United StatesL. P TUREK - Veterans Affairs Medical Center, Iowa City, Iowa 52240, United States
- Resource Type
- Journal article
- Publication Details
- European journal of cancer prevention, Vol.11(3), pp.295-305
- Publisher
- Lippincott Williams and Wilkins; Hagerstown, MD
- DOI
- 10.1097/00008469-200206000-00013
- PMID
- 12131663
- ISSN
- 0959-8278
- eISSN
- 1473-5709
- Language
- English
- Date published
- 2002
- Academic Unit
- Epidemiology; Pathology; Family and Community Medicine; Obstetrics and Gynecology; Otolaryngology
- Record Identifier
- 9984024513702771
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