Journal article
Ischemic Optic Neuropathy Decompression Trial: twenty-four-month update
Archives of ophthalmology (1960), Vol.118(6), pp.793-798
06/01/2000
DOI: 10.1001/archopht.118.6.793
PMID: 10865316
Abstract
OBJECTIVETo describe visual acuity outcomes of patients in the Ischemic Optic Neuropathy Decompression Trial (IONDT) after 24 months of follow-up.DESIGNThe IONDT is a single-masked, multicenter, randomized clinical trial.SETTINGSPatients were evaluated and followed up at 25 clinical centers located throughout the United States. Data were sent to and analyzed at a central coordinating center.PATIENTSTwo hundred fifty-eight patients 50 years or older with nonarteritic anterior ischemic optic neuropathy and visual acuity of 20/64 or worse, but better than no light perception, were randomized to either a careful follow-up group (n=131) or an optic nerve decompression surgery (ONDS) group (n=127). Of these, 174 continued participation for at least 24 months, 89 in the careful follow-up group and 85 in the ONDS group.METHODSRandomized patients underwent a standard visual acuity examination at 3, 6, 12, 18, and 24 months of follow-up. The primary outcome was a change of 3 lines or more of visual acuity, defined as a difference of 0.3 in logMAR scores, between baseline and 6 months of follow-up. A secondary outcome was mean change in visual acuity (in logMAR units) at 3, 6, 12, 18, and 24 months following baseline. These changes were estimated using available data from all randomized patients for whom we had data.RESULTSOf the 258 patients randomized, 143 (55.4%) were male, and 169 (65.5%) were 65 years or older. Mean visual acuity was statistically significantly improved from baseline value at all study visits and for both treatment groups, although visual acuity declined gradually in both groups after the 3-month visit. There were no significant differences between careful follow-up and ONDS in mean change in vision from the baseline and any follow-up time point. At 24 months of follow-up, 31.0% of patients in the careful follow-up group and 29.4% of patients in the ONDS group experienced an increase of 3 or more lines of vision compared with baseline acuity; 21.8% of patients in the careful follow-up group and 20.0% of patients in the ONDS group experienced a decrease of 3 or more lines. In patients who could read at least 1 letter on the Lighthouse chart, there was a gradual decline in mean visual acuity noted over time for both treatment groups, although acuity remained significantly better than at baseline.CONCLUSIONAnalysis of visual acuity data from patients enrolled in the IONDT at 24 months of follow-up confirms that there is no benefit of ONDS compared with careful follow-up in patients with nonarteritic anterior ischemic optic neuropathy. Arch Ophthalmol. 2000;118:793-798
Details
- Title: Subtitle
- Ischemic Optic Neuropathy Decompression Trial: twenty-four-month update
- Creators
- Kay Dickersin - Coordinating Center, University of Maryland School of MedicineSophia Chung - Anheuser-Busch Eye Institute, St. Louis University Health Sciences CenterJohn Kennerdell - Allegheny General HospitalPatricia Jones - State University of New YorkAnna Tyutyunikov - Allegheny General HospitalMichael Graham - State University of New YorkRussell Edwards - Allegheny General HospitalRichard Anderson - University of UtahCharlene Campbell - West Virginia UniversityTodd Goodglick - Allegheny General HospitalDeborah Lang - Allegheny General HospitalKimberly Peele - Allegheny General HospitalPatty Knaup - Anheuser-Busch Eye Institute, St. Louis University Health Sciences CenterDiana Mekelburg - Anheuser-Busch Eye Institute, St. Louis University Health Sciences CenterJohn Holds - Anheuser-Busch Eye Institute, St. Louis University Health Sciences CenterJohn Selhorst - Anheuser-Busch Eye Institute, St. Louis University Health Sciences CenterMark Malton - Carolinas Medical CenterEvelyn Brooks - Carolinas Medical CenterSonia Armstrong - Carolinas Medical CenterYvonne McCracken - Carolinas Medical CenterEugene Benjamin - Carolinas Medical CenterBarbara Kinsler - Carolinas Medical CenterCarol Dellinger - Carolinas Medical CenterTraci Hunter Medlin - Carolinas Medical CenterMike McOwen - Carolinas Medical CenterDonna Russell - Carolinas Medical CenterTimothy Saunders - Carolinas Medical CenterGregory Kosmorsky - Cleveland Clinic FoundationTina Kiss - Cleveland Clinic FoundationCate Reinhard - Cleveland Clinic FoundationJanet Edgerton - Cleveland Clinic FoundationTami Fecko - Cleveland Clinic FoundationSusannah Hanson - Cleveland Clinic FoundationBrian Kraus - Cleveland Clinic FoundationDeborah Ross - Cleveland Clinic FoundationNancy Tomsak - Cleveland Clinic FoundationPamela Vargo - Cleveland Clinic FoundationLori Levin - Doheny Eye InstituteKristin Anderson - Doheny Eye InstituteLaura Walsh - Cleveland Clinic FoundationRufus Willis - Cleveland Clinic FoundationKerry Zimmerman - Doheny Eye InstituteRichard Cortez - Doheny Eye InstituteSteven Feldon - Doheny Eye InstituteKaren Deblanc - Doheny Eye InstituteJudy Hulse - Doheny Eye InstituteRichard Morales - Doheny Eye InstituteTracy Nichols - Doheny Eye InstituteLillian Reyes - Doheny Eye InstituteNadine Rodarte-Ochoa - Doheny Eye InstituteDaniel Romo - Doheny Eye InstituteAlfredo Sadun - Doheny Eye InstituteMary Steber - Doheny Eye InstituteFrances Walonker - Doheny Eye InstituteNancy J Newman - Emory UniversityDonna Loupe - Emory UniversityDiana Coffman - Emory UniversityHarvey Cole - Emory UniversityTed Wojno - Doheny Eye InstituteBarry Skarf - Henry Ford HospitalColleen Wojtala - Henry Ford HospitalMark Croswell - Henry Ford HospitalWendy Gilroy - Henry Ford HospitalChristian Mageli - Henry Ford HospitalDena McDonald - Henry Ford HospitalGeorge Ponka - Henry Ford HospitalRosa Tang - University of TexasMelissa Hamlin - University of TexasJewel Curtis - University of TexasKenneth Hyde - University of TexasKirk Mack - University of TexasPortia Tello - University of TexasAnthony Arnold - Jules Stein Eye InstituteMargaret Mullen - Jules Stein Eye InstituteBernice Cibener - Jules Stein Eye InstituteMelody Vega - Jules Stein Eye InstituteBobbi Ballenberg - Jules Stein Eye InstituteLynn Gordon - Jules Stein Eye InstituteHoward Krauss - Jules Stein Eye InstituteAnne Bolton - Jules Stein Eye InstituteJesus Garcia - Jules Stein Eye InstituteMichael Heneghan - Jules Stein Eye InstituteRobert Goldberg - Jules Stein Eye InstituteJackie Sanguinet - Jules Stein Eye InstituteRobert Stalling - Jules Stein Eye InstituteJenja Yadegaran - Jules Stein Eye InstituteWayne Cornblath - W.K. Kellogg Eye Center, University of MichiganBarbara Michael - W.K. Kellogg Eye Center, University of MichiganDonna Campbell - W.K. Kellogg Eye Center, University of MichiganCheryl Caudill - W.K. Kellogg Eye Center, University of MichiganChristine Nelson - W.K. Kellogg Eye Center, University of MichiganJonathan Trobe - W.K. Kellogg Eye Center, University of MichiganLenworth N Johnson - Mason Institute of Ophthalmology, University of MissouriGaye Baker - Mason Institute of Ophthalmology, University of MissouriCoy Cobb - Mason Institute of Ophthalmology, University of MissouriPhilip Custer - Mason Institute of Ophthalmology, University of MissouriSharon Turner - Mason Institute of Ophthalmology, University of MissouriRoy Wilson - Mason Institute of Ophthalmology, University of MissouriBrian Younge - Mayo ClinicJacqueline Leavitt - Mayo ClinicRebecca Nielsen - Mayo ClinicJody Allen - Mayo ClinicBarbara Eickhoff - Mayo ClinicJames Garrity - Mayo ClinicJacqueline Ladsten - Mayo ClinicKathleen Lebarron - Mayo ClinicThomas Link - Mayo ClinicJay Rostvold - Mayo ClinicKaren Weber - Mayo ClinicWarren Felton - Medical College of VirginiaTracy Oliver - Medical College of VirginiaSylvia Smith - Medical College of VirginiaDanielle Gabriel - Medical College of VirginiaDaniel David - Medical College of VirginiaLahn Fendelander - Medical College of VirginiaDaniel Geller - Medical College of VirginiaTimothy Jordan - Medical College of VirginiaChristian Kim - Medical College of VirginiaCraig Munger - Medical College of VirginiaJo Anne Romandy - Medical College of VirginiaGeorge Sanborn - Medical College of VirginiaBradley Schwartz - Medical College of VirginiaCarl Sheusi - Medical College of VirginiaConstance Smith - Medical College of VirginiaKathy Talley - Medical College of VirginiaSandya Thimmappa - Medical College of VirginiaDavid Kaufman - Michigan State UniversityEric Eggenberger - Michigan State UniversitySuzanne Bickert - Michigan State UniversityRobert Granadier - Michigan State University, William Beaumont HospitalSandra Holliday - Michigan State UniversityThomas Moore - Michigan State UniversityJaya Varadarajan - Michigan State UniversityDeborah Friedman - State University of New YorkHaris Amin - State University of New YorkThomas Bersani - State University of New YorkCynthia Briglin - State University of New YorkJames Fooks - State University of New YorkMilton James - State University of New YorkGary Michalec - State University of New YorkHoang Nguyen - State University of New YorkJonathan Horton - University of CaliforniaMaeve Chang - University of CaliforniaLou Anne Aber - University of CaliforniaErik Lindstrom - University of CaliforniaStuart R Seiff - University of CaliforniaJohn Guy - University of FloridaZ. Suzanne Zam - University of FloridaAmye Francis - University of FloridaLatif Hamed - University of FloridaAlan Lessner - University of FloridaDonna McDavid - University of FloridaDiana Shamis - University of FloridaJames Goodwin - University of IllinoisMartin E Lindeman - University of IllinoisErlinda Sullivan - University of IllinoisPhyllis Bobak - University of IllinoisAllen PuttermanDavid Cowen - University of KentuckyRobert Baker - University of KentuckyJudy Beck - University of KentuckyAvom Epstein - University of KentuckyMichael Hanson - University of KentuckyToni Scoggins - University of KentuckyShalom Kelman - University of Maryland, Chairman’s Office, University of Maryland School of MedicineCharlotte Frank - University of Maryland, Chairman’s Office, University of Maryland School of MedicineAndrea Blake - University of Maryland, Chairman’s Office, University of Maryland School of MedicineAnn M Rodavitch - University of Maryland, Chairman’s Office, University of Maryland School of MedicineBrenda Gore - University of MarylandMichelle Heroux - University of MarylandRani Kalsi - University of MarylandCharlene Krauch - University of MarylandMary Ann Millar - University of MarylandKakarla Chalam - University of South CarolinaMitchell Wolin - University of South CarolinaBeth Munn - University of South CarolinaRita Jean Brady - University of South CarolinaRegina Hansen - University of South CarolinaMichael Briggs - University of South CarolinaBarbara Danner - University of South CarolinaBeverly Simons - University of South CarolinaAnne Stewart - University of South CarolinaKathleen Digre - University of UtahJodi Erickson - University of UtahLizbeth Malmquist-Webb - University of UtahTerrell Blackburn - University of UtahSusan Baggaley - University of UtahCharles Juarez - University of UtahBonnie Kaye - University of UtahPaul Langer - University of UtahAditya Mishra - University of UtahPaula Morris - University of UtahSandra Osborn - University of UtahBhupendra Patel - University of UtahSandra Staker - University of UtahJudith Warner - University of UtahSteven Newman - University of VirginiaChristine Evans - University of VirginiaAllison Aylor - University of VirginiaCarolyn Childress - University of VirginiaHelen Dickerson - University of VirginiaJane Fleming - University of VirginiaNomine Harris - University of VirginiaL. Sharon Hoyle - University of VirginiaEllen Murphy - University of VirginiaJames Scott - University of VirginiaTerri Small - University of VirginiaKaren Summerville - University of VirginiaMariann Terrell - University of VirginiaLillian Tyler - University of VirginiaJohn Lindberg - West Virginia UniversityBrian Ellis - West Virginia UniversityLenore Breen - West Virginia UniversityMichelle Michael - West Virginia UniversityNancy Groves - West Virginia UniversityRobert Hobson - West Virginia UniversityGordon McGregor - West Virginia UniversityLaura Shepherd - West Virginia UniversityEdward Cohn - William Beaumont HospitalKristi Cumming - William Beaumont HospitalPatricia Manatrey - William Beaumont HospitalSara Casey - William Beaumont HospitalJohn Johnson - William Beaumont HospitalColetti Kronner - William Beaumont HospitalVirginia Regan - William Beaumont HospitalPatricia Streasick - William Beaumont HospitalMichael Elman - Chairman’s Office, University of Maryland School of Medicine, Coordinating Center, University of Maryland School of MedicineDeborah Metzel - Chairman’s Office, University of Maryland School of MedicineFrank Hooper - Coordinating Center, University of Maryland School of MedicineRoberta Scherer - Coordinating Center, University of Maryland School of MedicineBarbara Crawley - Coordinating Center, University of Maryland School of MedicineCheryl Hiner - Coordinating Center, University of Maryland School of MedicineLucy Howard - Coordinating Center, University of Maryland School of MedicinePatricia Langenberg - Coordinating Center, University of Maryland School of MedicineOlga Lurye - Coordinating Center, University of Maryland School of MedicineJanet Masiero - Coordinating Center, University of Maryland School of MedicineRobert McCarter - Coordinating Center, University of Maryland School of MedicineSara Riedel - Coordinating Center, University of Maryland School of MedicineMichelle Sotos - Coordinating Center, University of Maryland School of MedicineLaureen Spioch - Coordinating Center, University of Maryland School of MedicineJoan Starr - Coordinating Center, University of Maryland School of MedicineJudy Urban - Coordinating Center, University of Maryland School of MedicineMark Waring - Coordinating Center, University of Maryland School of MedicineP David Wilson - Coordinating Center, University of Maryland School of MedicineDonald Everett - National Eye InstituteMarian FisherPhil AitkenRoy BeckAndrea LacroixSimmons LessellReverend Kenneth MacleanShalom KelmonIschemic Optic Neuropathy Decompression Trial Research Group
- Resource Type
- Journal article
- Publication Details
- Archives of ophthalmology (1960), Vol.118(6), pp.793-798
- DOI
- 10.1001/archopht.118.6.793
- PMID
- 10865316
- NLM abbreviation
- Arch Ophthalmol
- ISSN
- 0003-9950
- eISSN
- 1538-3601
- Publisher
- American Medical Association
- Language
- English
- Date published
- 06/01/2000
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984112004002771
Metrics
28 Record Views