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Ischemic cerebrovascular complications and risk factors in idiopathic hypertrophic subaortic stenosis
Journal article   Open access   Peer reviewed

Ischemic cerebrovascular complications and risk factors in idiopathic hypertrophic subaortic stenosis

James W Russell, José Biller, Zina D Hajduczok, Michael P Jones, Richard E Kerber and Harold P Adams Jr
Stroke (1970), Vol.22(9), pp.1143-1147
09/1991
DOI: 10.1161/01.STR.22.9.1143
PMID: 1822968
url
https://doi.org/10.1161/01.STR.22.9.1143View
Published (Version of record) Open Access

Abstract

To determine the risk and time to cerebrovascular complications with idiopathic hypertrophic subaortic stenosis, we studied 119 patients (66 men and 53 women) with evidence of this disease based on strict echocardiographic criteria and followed them up for a mean +/- SEM of 6.5 +/- 0.6 years. Cerebral ischemic events occurred in 26 patients (22%), and in five patients stroke was the initial presenting event. Men had cardiac symptoms at a younger age than women, but there was no significant difference in age at the time of stroke. Cardioembolic cerebrovascular events were associated with atrial fibrillation and left atrial enlargement, whereas atheroembolic events were associated with hypertension. An increased risk of stroke was associated with female sex, mitral anulus calcification, hypertension, and atrioventricular conduction delay. Unlike most previous series, this study shows that patients with idiopathic hypertrophic subaortic stenosis may present with stroke.
 Echocardiography Age Factors Humans Middle Aged Risk Factors Male Cardiomyopathy, Hypertrophic - complications Brain Ischemia - etiology Cerebrovascular Disorders - etiology Cerebrovascular Disorders - diagnosis Sex Factors Brain Ischemia - diagnosis Adult Female Aged

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