Journal article
Islet Cell Yield Following Remote Total Pancreatectomy With Islet Autotransplant is Independent of Cold Ischemia Time
Pancreas, Vol.46(3), pp.380-384
03/01/2017
DOI: 10.1097/MPA.0000000000000792
PMCID: PMC5308539
PMID: 28129232
Abstract
Objectives: Total pancreatectomy with islet autotransplantation is increasingly being performed remotely, that is, removing the pancreas in 1 location, isolating the islet cells in another location, then returning the islets to the original location for reimplantation into the patient. We determined the influence of extended cold ischemia time on key clinical outcomes in remote islet autotransplantation.
Methods: We evaluated patients who underwent remote islet autotransplantation at 2 centers from 2011 to 2014. Patients were divided into 2 groups: those with and those without a decrease in C-peptide greater than 50% from baseline. The primary clinical outcome was the quantity of isolated islet equivalents per kilogram body weight (IEQs/kg).
Results: Twenty-five patients met inclusion criteria; 15 had a decrease in C-peptide greater than 50% from baseline and had lower corresponding IEQs/kg compared with those without a decrease greater than 50% (4045 vs 6654 IEQs/kg, P = 0.01). There was no difference in cold ischemia time between the 2 groups (664 vs 600 minutes, P = 0.25). Daily insulin use at 1 year nearly met statistical significance (25.3 vs 8 U, P = 0.06), as did glycated hemoglobin (8.07 vs 6.69 mmol/L, P = 0.06).
Conclusions: Cold ischemia time does not influence islet yield in patients undergoing pancreatectomy with remote isolation.
Details
- Title: Subtitle
- Islet Cell Yield Following Remote Total Pancreatectomy With Islet Autotransplant is Independent of Cold Ischemia Time
- Creators
- Samuel J. Kesseli - Dartmouth–Hitchcock Medical CenterKerrington D. Smith - Dartmouth CollegeMin K. Jung - Cleveland ClinicYu K. Lin - Cleveland ClinicR. Matthew Walsh - SurgeryBetul Hatipoglu - Cleveland ClinicDavid A. Axelrod - Dartmouth–Hitchcock Medical CenterSushela S. Chaidarun - Dartmouth CollegeTyler K. Stevens - Cleveland Clin Fdn, Sect Gastroenterol & Hepatol, Inst Digest Dis, 9500 Euclid Ave, Cleveland, OH 44195 USATimothy B. Gardner - Dartmouth College
- Resource Type
- Journal article
- Publication Details
- Pancreas, Vol.46(3), pp.380-384
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/MPA.0000000000000792
- PMID
- 28129232
- PMCID
- PMC5308539
- ISSN
- 0885-3177
- eISSN
- 1536-4828
- Number of pages
- 5
- Grant note
- 1K23DK088832 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K23DK088832 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 03/01/2017
- Academic Unit
- Surgery
- Record Identifier
- 9984322794402771
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