Islet inflammation: a unifying target for diabetes treatment?

Yumi Imai; Anca D Dobrian; Margaret A Morris; Jerry L Nadler

doi:10.1016/j.tem.2013.01.007

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Islet inflammation: a unifying target for diabetes treatment?

Journal article

Open access

Peer reviewed

Islet inflammation: a unifying target for diabetes treatment?

Yumi Imai, Anca D Dobrian, Margaret A Morris and Jerry L Nadler

Trends in endocrinology and metabolism, Vol.24(7), pp.351-360

07/2013

DOI: 10.1016/j.tem.2013.01.007

PMCID: PMC3686848

PMID: 23484621

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Abstract

In the past decade, islet inflammation has emerged as a contributor to the loss of functional β cell mass in both type 1 (T1D) and type 2 diabetes (T2D). Evidence supports the idea that overnutrition and insulin resistance result in the production of proinflammatory mediators by β cells. In addition to compromising β cell function and survival, cytokines may recruit macrophages into islets, thus augmenting inflammation. Limited but intriguing data imply a role of adaptive immune response in islet dysfunction in T2D. Clinical trials have validated anti-inflammatory therapies in T2D, whereas immune therapy for T1D remains challenging. Further research is required to improve our understanding of islet inflammatory pathways and to identify more effective therapeutic targets for T1D and T2D.

Clinical Trials

Obesity

cytokine

β cell

immune cells

adipocyte

Details

Title: Subtitle: Islet inflammation: a unifying target for diabetes treatment?
Creators: Yumi Imai - Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
Anca D Dobrian - Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
Margaret A Morris - Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
Jerry L Nadler - Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
Resource Type: Journal article
Publication Details: Trends in endocrinology and metabolism, Vol.24(7), pp.351-360
DOI: 10.1016/j.tem.2013.01.007
PMID: 23484621
PMCID: PMC3686848
NLM abbreviation: Trends Endocrinol Metab
ISSN: 1043-2760
eISSN: 1879-3061
Publisher: Elsevier Ltd
Language: English
Date published: 07/2013
Academic Unit: Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984094659802771

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