Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis

Samantha N Jensen; Nicole M Cady; Shailesh K Shahi; Stephanie R Peterson; Arnav Gupta; Katherine N Gibson-Corley; Ashutosh K Mangalam

doi:10.1126/sciadv.abd4595

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Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis

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Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis

Samantha N Jensen, Nicole M Cady, Shailesh K Shahi, Stephanie R Peterson, Arnav Gupta, Katherine N Gibson-Corley and Ashutosh K Mangalam

Science advances, Vol.7(28), eabd4595

07/01/2021

DOI: 10.1126/sciadv.abd4595

PMCID: PMC8270496

PMID: 34244137

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270496View

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Abstract

The gut microbiota is a potential environmental factor that influences the development of multiple sclerosis (MS). We and others have demonstrated that patients with MS and healthy individuals have distinct gut microbiomes. However, the pathogenic relevance of these differences remains unclear. Previously, we showed that bacteria that metabolize isoflavones are less abundant in patients with MS, suggesting that isoflavone-metabolizing bacteria might provide protection against MS. Here, using a mouse model of MS, we report that an isoflavone diet provides protection against disease, which is dependent on the presence of isoflavone-metabolizing bacteria and their metabolite equol. Notably, the composition of the gut microbiome in mice fed an isoflavone diet exhibited parallels to healthy human donors, whereas the composition in those fed an isoflavone-free diet exhibited parallels to patients with MS. Collectively, our study provides evidence that dietary-induced gut microbial changes alleviate disease severity and may contribute to MS pathogenesis.

Details

Title: Subtitle: Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis
Creators: Samantha N Jensen - University of Iowa
Nicole M Cady - University of Michigan
Shailesh K Shahi - University of Iowa
Stephanie R Peterson - University of Iowa
Arnav Gupta - National Institute of Science and Technology
Katherine N Gibson-Corley - University of Iowa
Ashutosh K Mangalam - University of Iowa
Resource Type: Journal article
Publication Details: Science advances, Vol.7(28), eabd4595
DOI: 10.1126/sciadv.abd4595
PMID: 34244137
PMCID: PMC8270496
NLM abbreviation: Sci Adv
eISSN: 2375-2548
Grant note: DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases, award: 1R01AI137075; DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases, award: T32AI007485; DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: P30 ES005605; DOI: 10.13039/100017206, name: Academia Militar, award: 1R01AI137075; DOI: 10.13039/100017206, name: Academia Militar, award: P30 ES005605; DOI: 10.13039/100017206, name: Academia Militar, award: T32AI007485; DOI: 10.13039/100017206, name: Academia Militar, award: 1R01AI137075
Language: English
Date published: 07/01/2021
Academic Unit: The University of Iowa Institute for Vision Research; Pathology; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9984186579202771

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