Isolated Placental Inflammation and Vasculopathy: Clinical Implications in the Extremely Low Birth Weight Infants

Rita P Verma; Yuan Zhao; Ram Niwas; Cynthia Kaplan

doi:10.1080/15513815.2016.1179378

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Isolated Placental Inflammation and Vasculopathy: Clinical Implications in the Extremely Low Birth Weight Infants

Journal article

Peer reviewed

Isolated Placental Inflammation and Vasculopathy: Clinical Implications in the Extremely Low Birth Weight Infants

Rita P Verma, Yuan Zhao, Ram Niwas and Cynthia Kaplan

Fetal and pediatric pathology, Vol.35(5), pp.299-306

09/02/2016

DOI: 10.1080/15513815.2016.1179378

PMID: 27223491

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Abstract

The predictive values of placental histopathologies are compromised by a non-segregation of common anomalies. The effects of isolated pure placental inflammation (PI) and vasculopathy-coagulopathy (PV) were compared with normal (NL) placentas in extremely premature infants (ELBW, birth weight < 1000 g). PI infants required lower peak inspiratory pressure on day 3. More infants in PV were oxygen dependence on day 28. PV had an increased risk of intraventricular-periventricular hemorrhage (IVH, OR 4.9, 95% CI 1-24.7, p = 0.05). NL infants were unexposed to PPROM or maternal hypertension, had highest requirement for surfactant, did not develop IVH and periventricular leukomalacia (PVL) and none of them were Caucasian. Conclusions: In ELBW infants (1) pure placental vasculopathy-coagulopathy is a risk factor for IVH, (2) a non- pathological intrauterine environment is nonconducive to IVH and PVL, (3) pure placental inflammation is protective for acute pulmonary disease, (4) Caucasian mothers are more susceptible to adverse intrauterine environment.

placental vasculopathy-coagulopathy

periventricular leukomalacia

Extremely low birth weight infants

placental inflammation

intraventricular-periventricular hemorrhage

Details

Title: Subtitle: Isolated Placental Inflammation and Vasculopathy: Clinical Implications in the Extremely Low Birth Weight Infants
Creators: Rita P Verma - Nassau County University Medical Center, State University of New York
Yuan Zhao - Department of Applied Mathematics and Statistics, State University of New York
Ram Niwas - University of Iowa
Cynthia Kaplan - Stony Brook Medicine
Resource Type: Journal article
Publication Details: Fetal and pediatric pathology, Vol.35(5), pp.299-306
Publisher: Taylor & Francis
DOI: 10.1080/15513815.2016.1179378
PMID: 27223491
ISSN: 1551-3815
eISSN: 1551-3823
Language: English
Date published: 09/02/2016
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984093502102771

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