Isolated abnormal strict morphology is not a contraindication for intrauterine insemination

G M Lockwood; N E Deveneau; A N Shridharani; E Y Strawn; J I Sandlow

doi:10.1111/andr.12098

Back

Isolated abnormal strict morphology is not a contraindication for intrauterine insemination

Journal article

Peer reviewed

Isolated abnormal strict morphology is not a contraindication for intrauterine insemination

G M Lockwood, N E Deveneau, A N Shridharani, E Y Strawn and J I Sandlow

Andrology (Oxford), Vol.3(6), pp.1088-1093

11/2015

DOI: 10.1111/andr.12098

PMID: 26384603

View Online

Abstract

This study sought to investigate whether isolated abnormal strict morphology (<5% normal forms) and very low strict morphology (0-1% normal forms) affects pregnancy rates in intrauterine insemination (IUI). This was a retrospective study performed at an Academic Medical Center/Reproductive Medicine Center. Four hundred and eight couples were included for 856 IUI cycles. 70 IUI cycles were performed in couples with abnormal strict morphology and otherwise normal semen parameters. Outcomes were measured as clinical pregnancy rate per IUI cycle as documented by fetal heart activity on maternal ultrasound. Clinical pregnancy rate did not significantly differ between the group with abnormal strict morphology [11/70 (15.7%)] and the normal morphology group [39/281 (13.9%)]. Additionally, there was no significant difference between the pregnancy rate in the abnormal morphology group compared to that of our overall institutional IUI pregnancy rate [145/856 (16.9%)]. Furthermore, there was no significant difference between pregnancy rate in the very low morphology group [3/14 (21.4%)] compared to those with normal morphology or the overall IUI pregnancy rate. Patients with isolated abnormal strict morphology have clinical pregnancy rates similar to those with normal morphology for IUI. Even in those with very low normal forms, consideration of IUI for assisted reproduction should not be excluded.

Pregnancy

Predictive Value of Tests

Spermatozoa - pathology

Humans

Risk Factors

Semen Analysis

Male

Treatment Outcome

Infertility, Male - pathology

Infertility, Male - physiopathology

Insemination, Artificial, Homologous

Adult

Female

Infertility, Male - therapy

Retrospective Studies

Pregnancy Rate

Details

Title: Subtitle: Isolated abnormal strict morphology is not a contraindication for intrauterine insemination
Creators: G M Lockwood - Department of Urology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA
N E Deveneau - Department of Obstetrics and Gynecology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA
A N Shridharani - Department of Urology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA
E Y Strawn - Department of Obstetrics and Gynecology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA
J I Sandlow - Department of Urology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA
Resource Type: Journal article
Publication Details: Andrology (Oxford), Vol.3(6), pp.1088-1093
DOI: 10.1111/andr.12098
PMID: 26384603
NLM abbreviation: Andrology
ISSN: 2047-2919
eISSN: 2047-2927
Publisher: England
Language: English
Date published: 11/2015
Academic Unit: Stead Family Department of Pediatrics; Urology
Record Identifier: 9984051798902771

Metrics

25 Record Views

26 Times Cited - Web of Science

See more details