Journal article
Isolation, Synthesis, and Radical-Scavenging Activity of Rhodomelin A, a Ureidobromophenol from the Marine Red Alga Rhodomela confervoides
Organic letters, Vol.20(2), pp.417-420
01/19/2018
DOI: 10.1021/acs.orglett.7b03716
PMID: 29285928
Abstract
A novel ureidobromophenol, rhodomelin A (1), was characterized from Rhodomela confervoides. Its structure was elucidated by spectroscopic analysis. Both enantiomers of 1 were synthesized using a convergent strategy starting from d/l-pyroglutamic acids, respectively, allowing assignment of the R-configuration for the naturally occurring isomer by chiral HPLC analysis. Rhodomelin A represents the first example of a naturally occurring ureidopyrrolidone alkaloid incorporating a γ-aminobutyric acid unit. The scavenging activity of 1 toward DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate)) radicals was assayed.
Details
- Title: Subtitle
- Isolation, Synthesis, and Radical-Scavenging Activity of Rhodomelin A, a Ureidobromophenol from the Marine Red Alga Rhodomela confervoides
- Creators
- Ke Li - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology of Qingdao National Laboratory for Marine Science and Technology , Nanhai Road 7, Qingdao 266071, ChinaYa-Fei Wang - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, and Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Yushan Road 5, Qingdao 266003, ChinaXiao-Ming Li - Institute of OceanologyWei-Jia Wang - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, and Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Yushan Road 5, Qingdao 266003, ChinaXu-Ze Ai - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, and Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Yushan Road 5, Qingdao 266003, ChinaXin Li - Institute of OceanologySui-Qun Yang - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology of Qingdao National Laboratory for Marine Science and Technology , Nanhai Road 7, Qingdao 266071, ChinaJames B Gloer - Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United StatesBin-Gui Wang - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology of Qingdao National Laboratory for Marine Science and Technology , Nanhai Road 7, Qingdao 266071, ChinaTao Xu - Ocean University of China
- Resource Type
- Journal article
- Publication Details
- Organic letters, Vol.20(2), pp.417-420
- Publisher
- United States
- DOI
- 10.1021/acs.orglett.7b03716
- PMID
- 29285928
- ISSN
- 1523-7060
- eISSN
- 1523-7052
- Grant note
- DOI: 10.13039/501100003091, name: Shandong Province; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 31330009, 81502913, U1606403, U1706213; name: Central Committee of the Communist Party of China; name: Qingdao National Laboratory for Marine Science and Technology, award: 2015ASTP-ES14
- Language
- English
- Date published
- 01/19/2018
- Academic Unit
- Chemistry
- Record Identifier
- 9983985944702771
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