Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain

Béatrice  Tourvieille; Scott D Gorman; Elizabeth H Field; Tim Hunkapiller; Jane R Parnes

doi:10.1126/science.3094146

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Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain

Journal article

Peer reviewed

Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain

Béatrice Tourvieille, Scott D Gorman, Elizabeth H Field, Tim Hunkapiller and Jane R Parnes

Science (American Association for the Advancement of Science), Vol.234(4776), pp.610-614

1986

DOI: 10.1126/science.3094146

PMID: 3094146

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Abstract

T lymphocytes express on their surface not only a specific receptor for antigen and major histocompatibility complex proteins, but also a number of additional glycoproteins that are thought to play accessory roles in the processes of recognition and signal transduction. L3T4 is one such T-cell surface protein that is expressed on most mouse thymocytes and on mature mouse T cells that recognize class II (Ia) major histocompatibility complex proteins. Such cells are predominantly of the helper/inducer phenotype. In this study, complementary DNA clones encoding L3T4 were isolated and sequenced. The predicted protein sequence shows that L3T4 is a member of the immunoglobulin gene superfamily. It is encoded by a single gene that does not require rearrangement prior to expression. Although the protein has not previously been demonstrated on nonhematopoietic cells, two messenger RNA species specific for L3T4 are found in brain. The minor species comigrates with the L3T4 transcript in T cells, whereas the major species is 1 kilobase smaller.

Molecular Genetics

Gene Expression

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Molecular and cellular biology

Details

Title: Subtitle: Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain
Creators: Béatrice Tourvieille - Stanford univ., medical center, Stanford CA 94305, United States
Scott D Gorman - Stanford univ., medical center, Stanford CA 94305, United States
Elizabeth H Field - Stanford univ., medical center, Stanford CA 94305, United States
Tim Hunkapiller - Stanford univ., medical center, Stanford CA 94305, United States
Jane R Parnes - Stanford univ., medical center, Stanford CA 94305, United States
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.234(4776), pp.610-614
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.3094146
PMID: 3094146
ISSN: 0036-8075
eISSN: 1095-9203
Language: English
Date published: 1986
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094769402771

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