Journal article
Isolation of a low-molecular-weight antibacterial system from human amniotic fluid
Infection and immunity, Vol.14(5), pp.1156-1166
11/1976
DOI: 10.1128/IAI.14.5.1156-1166.1976
PMCID: PMC415508
PMID: 789241
Abstract
A low-molecular-weight antibacterial system has been isolated from human amniotic fluid. The bacterial inhibitor requires the metal cation zinc and a peptide with a molecular weight of 630. The peptide component was purified using ultrafiltration, gel filtration, and ion-exchange chromatography. It can be inactivated by digestion with carboxypeptidase. The amino acid composition of the peptide is: 3 glutamine-glutamic acid, 2 glycine, and 1 lysine. Removal of zinc from the peptide has been shown to remove bacterial inhibitory activity.
Details
- Title: Subtitle
- Isolation of a low-molecular-weight antibacterial system from human amniotic fluid
- Creators
- Patrick SchlievertWilliam JohnsonRudolph P Galask
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.14(5), pp.1156-1166
- DOI
- 10.1128/IAI.14.5.1156-1166.1976
- PMID
- 789241
- PMCID
- PMC415508
- NLM abbreviation
- Infect Immun
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Publisher
- United States
- Language
- English
- Date published
- 11/1976
- Academic Unit
- Dermatology; Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002392202771
Metrics
24 Record Views