Journal article
Isoproterenol improves ability of lung to clear edema in rats exposed to hyperoxia
Journal of applied physiology (1985), Vol.87(1), pp.30-35
07/01/1999
DOI: 10.1152/jappl.1999.87.1.30
PMID: 10409555
Abstract
Exposure of adult rats to 100% O
2
results in lung injury and decreases active sodium transport and lung edema clearance. It has been reported that β-adrenergic agonists increase lung edema clearance in normal rat lungs by upregulating alveolar epithelial Na
+
-K
+
-ATPase function. This study was designed to examine whether isoproterenol (Iso) affects lung edema clearance in rats exposed to 100% O
2
for 64 h. Active Na
+
transport and lung edema clearance decreased by ∼44% in rats exposed to acute hyperoxia. Iso (10
−6
M) increased the ability of the lung to clear edema in room-air-breathing rats (from 0.50 ± 0.02 to 0.99 ± 0.05 ml/h) and in rats exposed to 100% O
2
(from 0.28 ± 0.03 to 0.86 ± 0.09 ml/h; P < 0.001). Disruption of intracellular microtubular transport of ion-transporting proteins by colchicine (0.25 mg/100 g body wt) inhibited the stimulatory effects of Iso in hyperoxia-injured rat lungs, whereas the isomer β-lumicolchicine, which does not affect microtubular transport, did not inhibit active Na
+
transport stimulated by Iso. Accordingly, Iso restored the lung’s ability to clear edema after hyperoxic lung injury, probably by stimulation of the recruitment of ion-transporting proteins (Na
+
-K
+
-ATPase) from intracellular pools to the plasma membrane in rat alveolar epithelium.
Details
- Title: Subtitle
- Isoproterenol improves ability of lung to clear edema in rats exposed to hyperoxia
- Creators
- F. J. Saldías - University of Illinois at ChicagoA. Comellas - University of Illinois at ChicagoK. M. Ridge - University of Illinois at ChicagoE. Lecuona - University of Illinois at ChicagoJ. I. Sznajder - University of Illinois at Chicago
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.87(1), pp.30-35
- DOI
- 10.1152/jappl.1999.87.1.30
- PMID
- 10409555
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 07/01/1999
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984359574102771
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