Journal article
Isoproterenol‐induced heart failure model in the rat: cardiac autonomic tone, left ventricular function and baroreflex sensitivity
The FASEB journal, Vol.24(S1), pp.lb561-lb561
04/2010
DOI: 10.1096/fasebj.24.1_supplement.lb561
Abstract
We investigated the cardiac autonomic tone, left ventricle function and baroreflex sensitivity in rats subjected to isoproterenol‐induced heart failure (HF). Male Sprague Dawley rats received 2 injections (separated by a 24‐hour interval) of isoproterenol (ISO; 170 mg/kg/day, sc; n=8) or vehicle (V; saline; sc; n=8). After 4 weeks, the rats were implanted with femoral artery and vein catheters and tested 3 days later. Cardiac autonomic tone, left ventricle function and baroreflex sensitivity were examined with intravenous injections of atropine (1 mg/kg) and propranolol (2 mg/kg), using Millar catheters and the sequence method. ISO treatment decreased basal HR (ISO 332 vs. V 351 bpm), intrinsic HR (ISO 327 vs. V 347 bpm) and reduced the tachycardia elicited by atropine (ISO 389 vs. V 427 bpm). However, propranolol elicited similar bradycardia in both groups. Rats treated with ISO showed decreased dP/dt+ (ISO 8047 vs. V 10167 mmHg/s) and dP/dt‐ (ISO 8149 vs. V 11428 mmHg/s), but no differences were observed in the baroreflex sensitivity (ISO 1.50 vs. V 1.46 ms/mmHg). Our results extend the characterization of the ISO‐induced HF model and demonstrate a decrease in the basal and intrinsic HR without any change in baroreflex sensitivity.
Details
- Title: Subtitle
- Isoproterenol‐induced heart failure model in the rat: cardiac autonomic tone, left ventricular function and baroreflex sensitivity
- Creators
- Daniel Penteado Martins Dias - University of IowaHelio Cesar Salgado - School of Medicine of Ribeirao Preto ‐ University of Sao PauloTerry G Beltz - University of IowaBaojian Xue - University of IowaAlan Kim Johnson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.24(S1), pp.lb561-lb561
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.24.1_supplement.lb561
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Health and Human Physiology; Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics)
- Record Identifier
- 9984213403202771
Metrics
2 Record Views