Journal article
Itaconate as a potential target for antimalarial therapy
Trends in parasitology, Vol.40(4), pp.275-277
04/2024
DOI: 10.1016/j.pt.2024.03.003
PMCID: PMC10994723
PMID: 38485579
Abstract
In a recent publication, Ramalho et al. investigated monocyte-derived dendritic cell (MODC) mobilization in response to Plasmodium infection. The authors showed that elevated levels of itaconate in MODCs results in reduced CD8 T cell activation and that the absence of itaconate is associated with enhanced parasite control.
In a recent publication, Ramalho et al. investigated monocyte-derived dendritic cell (MODC) mobilization in response to Plasmodium infection. The authors showed that elevated levels of itaconate in MODCs results in reduced CD8 T cell activation and that the absence of itaconate is associated with enhanced parasite control.
Details
- Title: Subtitle
- Itaconate as a potential target for antimalarial therapy
- Creators
- Jonathon P. Bernardi - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USATaylen J. Nappi - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USANoah S. Butler - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Trends in parasitology, Vol.40(4), pp.275-277
- DOI
- 10.1016/j.pt.2024.03.003
- PMID
- 38485579
- PMCID
- PMC10994723
- NLM abbreviation
- Trends Parasitol
- ISSN
- 1471-4922
- eISSN
- 1471-5007
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000060, name: NIAID, award: R01AI127481, R01AI125446, R01AI167058, T32AI007511
- Language
- English
- Electronic publication date
- 03/13/2024
- Date published
- 04/2024
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9984573659402771
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