It's not too late: the onset of the frontocentral P3 indexes successful response inhibition in the stop-signal paradigm

Jan R Wessel; Adam R Aron

doi:10.1111/psyp.12374

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It's not too late: the onset of the frontocentral P3 indexes successful response inhibition in the stop-signal paradigm

Journal article

Peer reviewed

It's not too late: the onset of the frontocentral P3 indexes successful response inhibition in the stop-signal paradigm

Jan R Wessel and Adam R Aron

Psychophysiology, Vol.52(4), pp.472-480

04/2015

DOI: 10.1111/psyp.12374

PMCID: PMC4830357

PMID: 25348645

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Abstract

The frontocentral P3 event-related potential has been proposed as a neural marker of response inhibition. However, this association is disputed: some argue that P3 latency is too late relative to the timing of action stopping (stop-signal reaction time; SSRT) to index response inhibition. We tested whether P3 onset latency is a marker of response inhibition, and whether it coincides with the timing predicted by neurocomputational models. We measured EEG in 62 participants during the stop-signal task, and used independent component analysis and permutation statistics to measure the P3 onset in each participant. We show that P3 onset latency is shorter when stopping is successful, that it is highly correlated with SSRT, and that it coincides with the purported timing of the inhibition process (towards the end of SSRT). These results demonstrate the utility of P3 onset latency as a noninvasive, temporally precise neural marker of the response inhibition process.

Event-Related Potentials, P300 - physiology

Humans

Male

Electroencephalography

Reaction Time - physiology

Brain - physiology

Neuropsychological Tests

Young Adult

Brain Mapping

Adult

Choice Behavior - physiology

Female

Inhibition (Psychology)

Details

Title: Subtitle: It's not too late: the onset of the frontocentral P3 indexes successful response inhibition in the stop-signal paradigm
Creators: Jan R Wessel - Psychology Department, University of California, San Diego, La Jolla, California, USA
Adam R Aron
Resource Type: Journal article
Publication Details: Psychophysiology, Vol.52(4), pp.472-480
DOI: 10.1111/psyp.12374
PMID: 25348645
PMCID: PMC4830357
NLM abbreviation: Psychophysiology
ISSN: 0048-5772
eISSN: 1540-5958
Publisher: United States
Grant note: R01DA026452 / NIDA NIH HHS R21 NS085543 / NINDS NIH HHS R01 DA026452 / NIDA NIH HHS
Language: English
Date published: 04/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002469002771

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