Journal article
Joint Spatial-Spectral Reconstruction and k-t Spirals for Accelerated 2D Spatial/1D Spectral Imaging of 13 C Dynamics
Magnetic resonance in medicine, Vol.71(4), pp.1435-1445
04/01/2014
DOI: 10.1002/mrm.24796
PMCID: PMC4011726
PMID: 23716402
Abstract
Purpose: To develop a novel imaging technique to reduce the number of excitations and required scan time for hyperpolarized C-13 imaging.
Methods: A least-squares based optimization and reconstruction is developed to simultaneously solve for both spatial and spectral encoding. By jointly solving both domains, spectral imaging can potentially be performed with a spatially oversampled single echo spiral acquisition. Digital simulations, phantom experiments, and initial in vivo hyperpolarized [1-C-13]pyruvate experiments were performed to assess the performance of the algorithm as compared to a multi-echo approach.
Results: Simulations and phantom data indicate that accurate single echo imaging is possible when coupled with oversampling factors greater than six (corresponding to a worst case of pyruvate to metabolite ratio < 9%), even in situations of substantial T-2(*) decay and B-0 heterogeneity. With lower oversampling rates, two echoes are required for similar accuracy. These results were confirmed with in vivo data experiments, showing accurate single echo spectral imaging with an oversampling factor of 7 and two echo imaging with an oversampling factor of 4.
Conclusion: The proposed k-t approach increases data acquisition efficiency by reducing the number of echoes required to generate spectroscopic images, thereby allowing accelerated acquisition speed, preserved polarization, and/or improved temporal or spatial resolution. (c) 2013 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Joint Spatial-Spectral Reconstruction and k-t Spirals for Accelerated 2D Spatial/1D Spectral Imaging of 13 C Dynamics
- Creators
- Jeremy W. Gordon - University of Wisconsin–MadisonDavid J. Niles - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–MadisonKevin M. Johnson - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.71(4), pp.1435-1445
- Publisher
- Wiley
- DOI
- 10.1002/mrm.24796
- PMID
- 23716402
- PMCID
- PMC4011726
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 11
- Grant note
- P50AG033514 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Department of Radiology, University of Wisconsin-Madison P30CA014520 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 1 P50AG033514 / NIH/NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) GE Healthcare; General Electric
- Language
- English
- Date published
- 04/01/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984275057302771
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