Journal article
Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR
Health psychology, Vol.26(3), pp.361-368
05/2007
DOI: 10.1037/0278-6133.26.3.361
PMID: 17500623
Abstract
To determine the relationship between joint variation in 2 dopaminergic genes and the likelihood of nonsmoking following treatment with bupropion sustained release (SR).
Three hundred twenty-three participants in a bupropion SR smoking cessation effectiveness trial with 12-month follow-up were genotyped for variants of dopamine receptor gene DRD2 and dopamine transporter SLC6A3.
Self-reported 7-day point prevalence of nonsmoking.
Neither genotype alone was associated with 7-day point-prevalent nonsmoking at the 12-month follow-up. However, in the presence of the DRD2 A1 allele, SLC6A3 status was significantly associated with the likelihood of nonsmoking at the 12-month follow-up (individuals with DRD2 A1+ and SLC6A3 9- were more likely to be smoking). In the absence of the DRD2 A1 allele, the association between SLC6A3 status and nonsmoking was nonsignificant.
Although these results are suggestive, a more compelling test is needed of the hypothesis that dopaminergic gene interaction underlies, in part, the likelihood of smoking following treatment with bupropion SR. Most likely this will come from larger studies involving prospective randomization to treatment based on genotype.
Details
- Title: Subtitle
- Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR
- Creators
- Gary E Swan - SRI InternationalLisa M Jack - SRI InternationalAna M Valdes - SRI InternationalHuijun Z Ring - SRI InternationalCarl C Ton - Fred Hutch Cancer CenterSusan J Curry - University of Illinois at ChicagoTim McAfee - Alere Wellbeing
- Resource Type
- Journal article
- Publication Details
- Health psychology, Vol.26(3), pp.361-368
- DOI
- 10.1037/0278-6133.26.3.361
- PMID
- 17500623
- ISSN
- 0278-6133
- eISSN
- 1930-7810
- Grant note
- R01 CA071358 / NCI NIH HHS CA71358 / NCI NIH HHS
- Language
- English
- Date published
- 05/2007
- Academic Unit
- Health Management and Policy; Community and Behavioral Health
- Record Identifier
- 9984366290602771
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