KELVIN: a software package for rigorous measurement of statistical evidence in human genetics

Veronica J Vieland; Yungui Huang; Sang-Cheol Seok; John Burian; Umit Catalyurek; Jeffrey O'Connell; Alberto Segre; William Valentine-Cooper

doi:10.1159/000330634

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KELVIN: a software package for rigorous measurement of statistical evidence in human genetics

Journal article

Open access

Peer reviewed

KELVIN: a software package for rigorous measurement of statistical evidence in human genetics

Veronica J Vieland, Yungui Huang, Sang-Cheol Seok, John Burian, Umit Catalyurek, Jeffrey O'Connell, Alberto Segre and William Valentine-Cooper

Human heredity, Vol.72(4), pp.276-288

2011

DOI: 10.1159/000330634

PMCID: PMC3267994

PMID: 22189470

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Abstract

This paper describes the software package KELVIN, which supports the PPL (posterior probability of linkage) framework for the measurement of statistical evidence in human (or more generally, diploid) genetic studies. In terms of scope, KELVIN supports two-point (trait-marker or marker-marker) and multipoint linkage analysis, based on either sex-averaged or sex-specific genetic maps, with an option to allow for imprinting; trait-marker linkage disequilibrium (LD), or association analysis, in case-control data, trio data, and/or multiplex family data, with options for joint linkage and trait-marker LD or conditional LD given linkage; dichotomous trait, quantitative trait and quantitative trait threshold models; and certain types of gene-gene interactions and covariate effects. Features and data (pedigree) structures can be freely mixed and matched within analyses. The statistical framework is specifically tailored to accumulate evidence in a mathematically rigorous way across multiple data sets or data subsets while allowing for multiple sources of heterogeneity, and KELVIN itself utilizes sophisticated software engineering to provide a powerful and robust platform for studying the genetics of complex disorders.

Chromosome Mapping

Epistasis, Genetic

Genetic Linkage

Genomic Imprinting

Humans

Linkage Disequilibrium

Models, Genetic

Models, Statistical

Pedigree

Quantitative Trait Loci

Software

Details

Title: Subtitle: KELVIN: a software package for rigorous measurement of statistical evidence in human genetics
Creators: Veronica J Vieland - Nationwide Children's Hospital
Yungui Huang
Sang-Cheol Seok
John Burian
Umit Catalyurek
Jeffrey O'Connell
Alberto Segre
William Valentine-Cooper
Resource Type: Journal article
Publication Details: Human heredity, Vol.72(4), pp.276-288
DOI: 10.1159/000330634
PMID: 22189470
PMCID: PMC3267994
NLM abbreviation: Hum Hered
eISBN: 3805599420; 9783805599429
ISSN: 0001-5652
eISSN: 1423-0062
Grant note: R01 MH086117 / NIMH NIH HHS MH086117 / NIMH NIH HHS
Language: English
Date published: 2011
Academic Unit: Nursing; Fraternal Order of Eagles Diabetes Research Center; Computer Science
Record Identifier: 9984259471902771

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