Journal article
KIM-1 and Kidney Disease Progression in Autosomal Dominant Polycystic Kidney Disease: HALT-PKD Results
American journal of nephrology, Vol.51(6), pp.473-479
06/01/2020
DOI: 10.1159/000508051
PMCID: PMC7384479
PMID: 32541154
Abstract
Background:Cyst compression of renal tubules plays a role in the progression of autosomal dominant polycystic kidney disease (ADPKD) and may induce expression of kidney injury molecule-1 (KIM-1). Whether urinary KIM-1 indexed for creatinine (uKIM-1/Cr) is a prognostic marker of disease progression in ADPKD is unknown.In this secondary analysis of a prospective cohort study, we sought to determine whether patients with high as opposed to low uKIM-1/CR at baseline had greater rates of eGFR loss and height-adjusted total kidney volume (HtTKV) increase.Methods:Baseline uKIM-1/Cr values were obtained from 754 participants in Halt Progression of Polycystic Kidney Disease (HALT-PKD) studies A (early ADPKD) and B (late ADPKD). The predictor was uKIM-1/Cr, which was dichotomized by a median value of 0.2417 pg/g, and the primary outcomes were measured longitudinally over time. Mixed-effects linear models were used in the analysis to calculate the annual slope of change in eGFR and HtTKV.Results:Patients with high uKIM-1/Cr (above the median) had an annual decline in eGFR that was 0.47 mL/min greater than that in those with low uKIM-1/Cr (p= 0.0015) after adjustment for all considered covariates. This association was seen in study B patients alone (0.45 mL/min;p= 0.009), but not in study A patients alone (0.42 mL/min;p= 0.06). High baseline uKIM-1/Cr was associated with higher HtTKV in the baseline cross-sectional analysis compared to low uKIM-1/Cr (p= 0.02), but there was no difference between the groups in the mixed-effects model annual slopes.Conclusion:Elevated baseline uKIM-1/Cr is associated with a greater decline in eGFR over time. Further research is needed to determine whether uKIM-1/Cr improves risk stratification in patients with ADPKD.
Details
- Title: Subtitle
- KIM-1 and Kidney Disease Progression in Autosomal Dominant Polycystic Kidney Disease: HALT-PKD Results
- Creators
- Benjamin R. Griffin - University of Iowa Hospitals and ClinicsZhiying You - University of Colorado Anschutz Medical CampusLama Noureddine - University of IowaBerenice Gitomer - University of Colorado Anschutz Medical CampusLoni Perrenoud - University of Colorado Anschutz Medical CampusWei Wang - University of Colorado Anschutz Medical CampusMichel Chonchol - University of Colorado Anschutz Medical CampusDiana Jalal - Iowa City VA Health Care SystemHALT Investigators
- Resource Type
- Journal article
- Publication Details
- American journal of nephrology, Vol.51(6), pp.473-479
- DOI
- 10.1159/000508051
- PMID
- 32541154
- PMCID
- PMC7384479
- NLM abbreviation
- Am J Nephrol
- ISSN
- 0250-8095
- eISSN
- 1421-9670
- Publisher
- Karger
- Number of pages
- 7
- Grant note
- Zell Family Foundation R01HL134738; T32 DK 007135; NIDDK R01 DK121516 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA W81XWH-17-0382 / Department of Defense; United States Department of Defense
- Language
- English
- Date published
- 06/01/2020
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359683802771
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