Keeping T cell memories in mind

Madison R Mix; John T Harty

doi:10.1016/j.it.2022.10.001

Back

Journal article

Peer reviewed

Keeping T cell memories in mind

Madison R Mix and John T Harty

Trends in immunology, Vol.43(12), pp.1018-1031

11/08/2022

DOI: 10.1016/j.it.2022.10.001

PMCID: PMC9691610

PMID: 36369103

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/9691610View

Open Access

Abstract

The mammalian central nervous system (CNS) contains a vibrant community of resident adaptive immune cells at homeostasis. Among these are memory CD8+ and CD4+ T cells, which reside in the CNS in the settings of health, aging, and neurological disease. These T cells commonly exhibit a tissue-resident memory (TRM) phenotype, suggesting that they are antigen-experienced and remain separate from the circulation. Despite these characterizations, T cell surveillance of the CNS has only recently been studied through the lens of TRM immunology. In this Review, we outline emerging concepts of CNS TRM generation, localization, maintenance, function, and specificity. In this way, we hope to highlight roles of CNS TRM in health and disease to inform future studies of adaptive neuroimmunity.

Details

Title: Subtitle: Keeping T cell memories in mind
Creators: Madison R Mix
John T Harty
Resource Type: Journal article
Publication Details: Trends in immunology, Vol.43(12), pp.1018-1031
DOI: 10.1016/j.it.2022.10.001
PMID: 36369103
PMCID: PMC9691610
NLM abbreviation: Trends Immunol
eISSN: 1471-4981
Grant note: DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases, award: AI042767, AI114543, AI167847, 5T32GM007337; DOI: 10.13039/100008893, name: University of Iowa; DOI: 10.13039/100000002, name: National Institutes of Health
Language: English
Date published: 11/08/2022
Academic Unit: Pathology
Record Identifier: 9984318254302771

Metrics

16 Record Views

10 Times Cited - Web of Science