Journal article
Ketorolac After Free Tissue Transfer: A Comparative Effectiveness Study
Annals of otology, rhinology & laryngology, Vol.123(6), pp.446-449
06/2014
DOI: 10.1177/0003489414526849
PMID: 24690984
Abstract
Objective: We sought to compare postoperative pain and complications in patients undergoing free tissue transfer for reconstruction of head and neck defects with and without ketorolac.
Methods: In this retrospective cohort study, we identified patients who underwent head and neck free tissue transfer procedures at the University of Iowa between July 2010 and December 2012. A subset of patients received ketorolac as an anti-platelet agent. Main outcome measures include postoperative analgesic use, pain scores, and bleeding complications.
Results: We identified 138 free tissue transfers, with 42 procedures in the ketorolac cohort. In the first 7 postoperative days, patients in the ketorolac and non-ketorolac cohorts received equivalent narcotic doses (morphine equivalents, 48.9 mg/day vs 46.6 mg/day, P = .72). The ketorolac group reported higher mean pain scores (3.1 vs 2.4, P = .004). Ketorolac use was not associated with need for transfusion (P = .86) or number of days with neck drains (P = .79).
Conclusion: Ketorolac did not demonstrate a significant analgesic effect in this group of patients in terms of pain scores and opioid requirements. However, there also was no evidence to suggest a higher likelihood of bleeding complications. Ketorolac may be safely used as an anti-platelet agent, with narcotic requirements unchanged.
Details
- Title: Subtitle
- Ketorolac After Free Tissue Transfer: A Comparative Effectiveness Study
- Creators
- J. Robert Schleiffarth - Department of Otolaryngology–Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USARodrigo Bayon - Department of Otolaryngology–Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAKristi E Chang - Department of Otolaryngology–Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USADouglas J Van Daele - Department of Otolaryngology–Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USANitin A Pagedar - Department of Otolaryngology–Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.123(6), pp.446-449
- DOI
- 10.1177/0003489414526849
- PMID
- 24690984
- ISSN
- 0003-4894
- eISSN
- 1943-572X
- Language
- English
- Date published
- 06/2014
- Academic Unit
- Radiation Oncology; Medicine Administration; Otolaryngology
- Record Identifier
- 9984006462402771
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