Journal article
Kinematic analysis of the gait of adult sheep during treadmill locomotion: Parameter values, allowable total error, and potential for use in evaluating spinal cord injury
Journal of the neurological sciences, Vol.358(1-2), pp.107-112
11/15/2015
DOI: 10.1016/j.jns.2015.08.031
PMID: 26341152
Abstract
We are developing a novel intradural spinal cord (SC) stimulator designed to improve the treatment of intractable pain and the sequelae of SC injury. In-vivo ovine models of neuropathic pain and moderate SC injury are being implemented for pre-clinical evaluations of this device, to be carried out via gait analysis before and after induction of the relevant condition. We extend previous studies on other quadrupeds to extract the three-dimensional kinematics of the limbs over the gait cycle of sheep walking on a treadmill. Quantitative measures of thoracic and pelvic limb movements were obtained from 17 animals. We calculated the total-error values to define the analytical performance of our motion capture system for these kinematic variables. The post- vs. pre-injury time delay between contralateral thoracic and pelvic-limb steps for normal and SC-injured sheep increased by ~24s over 100 steps. The pelvic limb hoof velocity during swing phase decreased, while range of pelvic hoof elevation and distance between lateral pelvic hoof placements increased after SC injury. The kinematics measures in a single SC-injured sheep can be objectively defined as changed from the corresponding pre-injury values, implying utility of this method to assess new neuromodulation strategies for specific deficits exhibited by an individual.
•Gait analysis was applied successfully to sheep walking on a treadmill.•Stride durations were measured with mean total technique errors of ~8%.•Moderate spinal cord injury induced objectively-defined kinematic changes.•Ovine ambulation patterns will be used to test novel neuromodulation devices.
Details
- Title: Subtitle
- Kinematic analysis of the gait of adult sheep during treadmill locomotion: Parameter values, allowable total error, and potential for use in evaluating spinal cord injury
- Creators
- Sina Safayi - Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USANick D Jeffery - Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USASara K Shivapour - Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USAMahdi Zamanighomi - Department of Statistics, Stanford University, Stanford, CA, USATyler J Zylstra - Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USAJoshua Bratsch-Prince - Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USASaul Wilson - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USAChandan G Reddy - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USADouglas C Fredericks - Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USAGeorge T Gillies - Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, VA, USAMatthew A Howard - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of the neurological sciences, Vol.358(1-2), pp.107-112
- DOI
- 10.1016/j.jns.2015.08.031
- PMID
- 26341152
- NLM abbreviation
- J Neurol Sci
- ISSN
- 0022-510X
- eISSN
- 1878-5883
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 11/15/2015
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Neurosurgery; Otolaryngology
- Record Identifier
- 9984020616602771
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