Kinetic Analysis of 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) in Head and Neck Cancer Patients Before and Early After Initiation of Chemoradiation Therapy

Yusuf Menda; Laura L Boles Ponto; Kenneth J Dornfeld; Timothy J Tewson; G. Leonard Watkins; Michael K Schultz; John J Sunderland; Michael M Graham; John M Buatti

doi:10.2967/jnumed.108.058495

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Kinetic Analysis of 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) in Head and Neck Cancer Patients Before and Early After Initiation of Chemoradiation Therapy

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Kinetic Analysis of 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) in Head and Neck Cancer Patients Before and Early After Initiation of Chemoradiation Therapy

Yusuf Menda, Laura L Boles Ponto, Kenneth J Dornfeld, Timothy J Tewson, G. Leonard Watkins, Michael K Schultz, John J Sunderland, Michael M Graham and John M Buatti

The Journal of nuclear medicine (1978), Vol.50(7), pp.1028-1035

07/2009

DOI: 10.2967/jnumed.108.058495

PMCID: PMC2745313

PMID: 19525472

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Abstract

The purpose of this study was to investigate the kinetic behavior of 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) before and early after initiation of chemoradiation therapy in patients with squamous cell head and neck cancer. Methods: A total of 8 patients with head and neck cancer underwent 18F-FLT PET scans (7 patients at baseline and after 5 d [10 Gy] of radiation therapy given with concomitant chemotherapy and 1 patient only at baseline). Dynamic PET images were obtained with concurrent arterial or venous blood sampling. Kinetic parameters including the flux constant of 18F-FLT based on compartmental analysis (K-FLT), the Patlak influx constant (K-Patlak), and standardized uptake value (SUV) were calculated for the primary tumor and 18F-FLT–avid cervical lymph nodes for all scans. Results: Mean pretreatment values of uptake for the primary tumor and cervical nodes were 0.075 ± 0.006 min−1, 0.042 ± 0.004 min−1, and 3.4 ± 0.5 (mean ± SD) for K-FLT, K-Patlak, and SUV, respectively. After 10 Gy of radiation therapy, these values were 0.040 ± 0.01 min−1, 0.018 ± 0.016 min−1, and 1.8 ± 1.1 for K-FLT, K-Patlak, and SUV, respectively. For all lesions seen on pretherapy and midtherapy scans, the correlation was 0.90 between K-FLT and K-Patlak, 0.91 between K-FLT and SUV, and 0.99 between K-Patlak and SUV. Conclusion: The initial 18F-FLT uptake and change early after treatment in squamous head and neck tumors can be adequately characterized with SUV obtained at 45–60 min, which demonstrates excellent correlation with influx parameters obtained from compartmental and Patlak analyses.

18F-FLT

head and neck cancer

3′-deoxy-3′-18F-fluorothymidine

Details

Title: Subtitle: Kinetic Analysis of 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) in Head and Neck Cancer Patients Before and Early After Initiation of Chemoradiation Therapy
Creators: Yusuf Menda - Department of Radiology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
Laura L Boles Ponto - Department of Radiology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
Kenneth J Dornfeld - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
Timothy J Tewson - Department of Radiology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
G. Leonard Watkins - Department of Radiology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
Michael K Schultz - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
John J Sunderland - Department of Radiology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
Michael M Graham - Department of Radiology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
John M Buatti - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: The Journal of nuclear medicine (1978), Vol.50(7), pp.1028-1035
DOI: 10.2967/jnumed.108.058495
PMID: 19525472
PMCID: PMC2745313
ISSN: 0161-5505
eISSN: 1535-5667
Language: English
Date published: 07/2009
Academic Unit: Radiology; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984040287802771

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