Journal article
Kipukasins, Nucleoside Derivatives from Aspergillus versicolor
Journal of natural products (Washington, D.C.), Vol.70(8), pp.1308-1311
08/24/2007
DOI: 10.1021/np070241l
PMCID: PMC2532754
PMID: 17608440
Abstract
Seven new aroyl uridine derivatives (kipukasins A-G; 1-7) were isolated from solid-substrate fermentation cultures of two different Hawaiian isolates of Aspergillus versicolor. The structures of compounds 1-7 were determined by analysis of NMR and MS data. The nucleoside portion of lead compound 1 was assigned as uracil-1-β-D-ribofuranoside by spectral comparison with an authentic standard. The bioactivity of the original A. versicolor extracts was accounted for mainly by the presence of the known metabolite sterigmatocystin, but kipukasins A and B showed modest activity in assays against Gram-positive bacteria. © 2007 American Chemical Society and American Society of Pharmacognosy.
Details
- Title: Subtitle
- Kipukasins, Nucleoside Derivatives from Aspergillus versicolor
- Creators
- Ping Jiao - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Mycotoxin Research Unit, Agricultural Research Service, NationalCenter for Agricultural Utilization Research, USDA, Peoria, Illinois 61604Sanjay V Mudur - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Mycotoxin Research Unit, Agricultural Research Service, NationalCenter for Agricultural Utilization Research, USDA, Peoria, Illinois 61604James B Gloer - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Mycotoxin Research Unit, Agricultural Research Service, NationalCenter for Agricultural Utilization Research, USDA, Peoria, Illinois 61604Donald T Wicklow - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Mycotoxin Research Unit, Agricultural Research Service, NationalCenter for Agricultural Utilization Research, USDA, Peoria, Illinois 61604
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.70(8), pp.1308-1311
- DOI
- 10.1021/np070241l
- PMID
- 17608440
- PMCID
- PMC2532754
- NLM abbreviation
- J Nat Prod
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Publisher
- American Chemical Society
- Language
- English
- Date published
- 08/24/2007
- Academic Unit
- Chemistry
- Record Identifier
- 9984216590002771
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