Journal article
Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion
Journal of neurochemistry, Vol.97(6), pp.1546-1570
06/2006
DOI: 10.1111/j.1471-4159.2006.03987.x
PMID: 16805768
Abstract
Neurotransmitters and hormones are released from neurosecretory cells by exocytosis (fusion) of synaptic vesicles, large dense-core vesicles and other types of vesicles or granules. The exocytosis is terminated and followed by endocytosis (retrieval). More than fifty years of research have established full-collapse fusion and clathrin-mediated endocytosis as essential modes of exo-endocytosis. Kiss-and-run and vesicle reuse represent alternative modes, but their prevalence and importance have yet to be elucidated, especially in neurons of the mammalian CNS. Here we examine various modes of exo-endocytosis across a wide range of neurosecretory systems. Full-collapse fusion and kiss-and-run coexist in many systems and play active roles in exocytotic events. In small nerve terminals of CNS, kiss-and-run has an additional role of enabling nerve terminals to conserve scarce vesicular resources and respond to high-frequency inputs. Full-collapse fusion and kiss-and-run will each contribute to maintaining cellular communication over a wide range of frequencies.
Details
- Title: Subtitle
- Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion
- Creators
- Nobutoshi C Harata - Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USAAlexander M AravanisRichard W Tsien
- Resource Type
- Journal article
- Publication Details
- Journal of neurochemistry, Vol.97(6), pp.1546-1570
- Publisher
- England
- DOI
- 10.1111/j.1471-4159.2006.03987.x
- PMID
- 16805768
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- Language
- English
- Date published
- 06/2006
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025332302771
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