Journal article
Klotho: a novel regulator of calcium and phosphorus homeostasis
Pflügers Archiv, Vol.462(2), pp.185-193
08/2011
DOI: 10.1007/s00424-011-0950-5
PMID: 21442474
Abstract
Klotho which was originally identified as an anti-aging protein is emerging as a substance with multiple effects on many systems including mineral homeostasis. In addition to its membrane-bound function as a co-receptor for fibroblast growth factor-23, soluble Klotho exerts effects as a circulating substance in plasma and urine. Novel features of this system include its autocrine-paracrine-endocrine glycan-modifying enzymatic function in the urinary lumen on calcium and phosphate transporters. Klotho induces phosphaturia by inhibiting the proximal tubule Na-coupled phosphate transporter. The action of Klotho is enzymatic in nature which includes alteration of transport activity and the more traditional means of regulation by trafficking. Klotho reduces calciuria by its distal as a sialidase directly on the apical calcium channel. Desialidation of the channel exposes glycan residues that promote binding to galectin-1, resulting in stabilization of residence on the plasma membrane. Through its systematic as well as renal actions, Klotho is emerging as a principal calciophosphoregulatory hormone.
Details
- Title: Subtitle
- Klotho: a novel regulator of calcium and phosphorus homeostasis
- Creators
- Chou-Long Huang - Department of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-8856, USA. chou-long.huang@utsouthwestern.eduOrson W Moe
- Resource Type
- Journal article
- Publication Details
- Pflügers Archiv, Vol.462(2), pp.185-193
- DOI
- 10.1007/s00424-011-0950-5
- PMID
- 21442474
- ISSN
- 0031-6768
- eISSN
- 1432-2013
- Grant note
- DK 078596 / NIDDK NIH HHS HL096862 / NHLBI NIH HHS DK-079328 / NIDDK NIH HHS DK078708 / NIDDK NIH HHS DK081523 / NIDDK NIH HHS AI041612 / NIAID NIH HHS P30 DK079328 / NIDDK NIH HHS DK081423 / NIDDK NIH HHS
- Language
- English
- Date published
- 08/2011
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094587002771
Metrics
16 Record Views