Logo image
Back
Knee Pain and Structural Damage as Risk Factors for Incident Widespread Pain: Data From the Multicenter Osteoarthritis Study
Journal article   Open access   Peer reviewed

Knee Pain and Structural Damage as Risk Factors for Incident Widespread Pain: Data From the Multicenter Osteoarthritis Study

Lisa C Carlesso, Neil A Segal, Jeffrey R Curtis, Barton L Wise, Laura Frey Law, Michael Nevitt and Tuhina Neogi
Arthritis care & research (2010), Vol.69(6), pp.826-832
06/2017
DOI: 10.1002/acr.23086
PMCID: PMC5354981
PMID: 27636245
url
https://doi.org/10.1002/acr.23086View
Published (Version of record) Open Access

Abstract

To examine the longitudinal relationship of knee pain, radiographic osteoarthritis (OA), symptomatic knee OA, and knee pain severity to incident widespread pain. The Multicenter Osteoarthritis Study is a longitudinal cohort of persons with or at risk of knee OA. Participants were characterized as having consistent frequent knee pain, radiographic OA (Kellgren/Lawrence scale grade ≥2), symptomatic OA, and knee pain severity at the 60-month visit (baseline). Widespread pain was categorized as pain above and below the waist, on both sides of the body and axially, using a standard homunculus, excluding knee pain. Incident widespread pain was defined as the presence of widespread pain at 84 months in those who were free of widespread pain at baseline. We assessed the relationship of baseline radiographic OA, symptomatic OA, consistent frequent knee pain, and knee pain severity, respectively, with incident widespread pain using logistic regression, adjusting for potential confounders, including models with and without pain severity. At baseline, 1,129 subjects were eligible for analysis (mean ± SD age 66.7 ± 7.8 years; mean ± SD body mass index 30.1 ± 5.8 kg/m ; 52% women). Radiographic OA in either knee (adjusted odds ratio [OR ] 0.90 [95% confidence interval (95% CI) 0.63-1.30]; P = 0.587) was not associated with incident widespread pain. Baseline bilateral consistent frequent knee pain (OR 2.35 [95% CI 1.37-4.03]), bilateral symptomatic OA (OR 2.11 [95% CI 1.04-4.24]), and knee pain severity (worst knee) (OR 1.11 [95% CI 1.05-1.17]; P < 0.001) were significantly associated with incident widespread pain. Consistent frequent knee pain, symptomatic OA, and knee pain severity increased the risk of developing widespread pain, independently of structural pathology. These results suggest that knee pain, and not structural pathology, contributes to the onset of widespread pain.
 Prospective Studies Humans Middle Aged Osteoarthritis, Knee - diagnosis Risk Factors Male Arthralgia - diagnosis Arthralgia - epidemiology Osteoarthritis, Knee - epidemiology Incidence Pain Measurement - methods Female Aged Longitudinal Studies Cohort Studies Databases, Factual

Details

Metrics

16 Record Views
19 Times Cited - Web of Science
Logo image