Knee extensor strength does not protect against incident knee symptoms at 30 months in the multicenter knee osteoarthritis (MOST) cohort

Neil A Segal; James C Torner; David T Felson; Jingbo Niu; Leena Sharma; Cora E Lewis; Michael Nevitt

doi:10.1016/j.pmrj.2009.03.005

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Knee extensor strength does not protect against incident knee symptoms at 30 months in the multicenter knee osteoarthritis (MOST) cohort

Journal article

Peer reviewed

Knee extensor strength does not protect against incident knee symptoms at 30 months in the multicenter knee osteoarthritis (MOST) cohort

Neil A Segal, James C Torner, David T Felson, Jingbo Niu, Leena Sharma, Cora E Lewis and Michael Nevitt

PM & R, Vol.1(5), pp.459-465

05/2009

DOI: 10.1016/j.pmrj.2009.03.005

PMCID: PMC2763276

PMID: 19627933

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https://www.ncbi.nlm.nih.gov/pmc/articles/2763276View

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Abstract

Knee extensor weakness has not been associated consistently with the risk for incident knee pain. Additionally, the balance of hamstring-to-quadriceps strength (H:Q ratio) may affect risk and has not been studied. The authors determined whether knee extensor weakness or muscle imbalance is a risk factor for development of frequent knee pain or stiffness and whether the effect is modified by lower limb alignment. Observational study. Community. Community-dwelling adults ages 50-79 years with or at risk of knee osteoarthritis based on obesity, knee injury, or surgery. A total of 1269 knees from women and 1006 knees from men without frequent knee symptoms at baseline and with 15- or 30- month follow-up outcome data were included. Isokinetic knee extensor and flexor strength as well as radiographic hip-knee-ankle alignment were measured at baseline. H:Q ratio was dichotomized, with normal being considered to be >/=0.6. Frequent knee symptoms at 15- or 30-month follow-up (frequent knee pain, aching, or stiffness on most days of the past month reported at both telephone contact just before and at visit). Mean +/- SD age was 62.2 +/- 8.0 years and mean body mass index (BMI) was 30.1 +/- 5.4 kg/m(2). Mean peak knee extensor strength (KES) was 132.6 +/- 42.4 and 76.9 +/- 25.3 N.m in men and women, respectively. Approximately 50% of knees in men and 59% of knees in women had an H:Q ratio <0.6. A total of 307 of 2275 eligible knees developed frequent knee symptoms at follow-up. Logistic regression controlling for age, BMI, femoral neck bone mineral density, activity score, and baseline Kellgren Lawrence grade revealed that neither KES nor H:Q ratio predicted the development of knee symptoms in gender-stratified or combined analyses. These results were unaffected by adjusting for lower limb alignment. Neither concentric quadriceps strength nor H:Q ratios predicted the development of frequent knee symptoms at 15- or 30-month follow-up in this cohort.

Humans

Middle Aged

Male

Arthralgia - epidemiology

Quadriceps Muscle - physiopathology

Case-Control Studies

Incidence

Weight-Bearing - physiology

Osteoarthritis, Knee - complications

Range of Motion, Articular - physiology

Female

Aged

Postural Balance - physiology

Osteoarthritis, Knee - physiopathology

Cohort Studies

Muscle Strength - physiology

Details

Title: Subtitle: Knee extensor strength does not protect against incident knee symptoms at 30 months in the multicenter knee osteoarthritis (MOST) cohort
Creators: Neil A Segal - Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, 0728 JPP, Iowa City, IA 52242-1088, USA. segal-research@uiowa.edu
James C Torner
David T Felson
Jingbo Niu
Leena Sharma
Cora E Lewis
Michael Nevitt
Resource Type: Journal article
Publication Details: PM & R, Vol.1(5), pp.459-465
DOI: 10.1016/j.pmrj.2009.03.005
PMID: 19627933
PMCID: PMC2763276
NLM abbreviation: PM R
ISSN: 1934-1482
eISSN: 1934-1563
Publisher: United States
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS U01 AG18947 / NIA NIH HHS U01 AG18832 / NIA NIH HHS U01 AG019069 / NIA NIH HHS U01 AG018832-07 / NIA NIH HHS K23 AG030945-02 / NIA NIH HHS U01 AG18820 / NIA NIH HHS K23 AG030945 / NIA NIH HHS U01 AG018820-07 / NIA NIH HHS R01 HD043502 / NICHD NIH HHS U01 AG018947-07 / NIA NIH HHS R01 HD43502 / NICHD NIH HHS U01 AG19069 / NIA NIH HHS U01 AG019069-07 / NIA NIH HHS K23AG030945 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 05/2009
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995030202771

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