Journal article
Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.70(3), pp.339-344
03/2015
DOI: 10.1093/gerona/glu102
PMCID: PMC4351392
PMID: 25063080
Abstract
Knee osteoarthritis (OA) and frailty are two conditions that are associated with functional limitation and disability in elders, yet their relation to one another is not known.
We included participants from two large, multicenter studies enriched with community dwelling older adults with knee OA (Multicenter Osteoarthritis Study and Osteoarthritis Initiative). Knee OA was defined radiographically (ROA) and symptomatically (SOA). Frailty was defined using the Study of Osteoporotic Fracture index as the presence of ≥2 of the following: (i) weight loss >5% between two consecutive visits; (ii) inability to arise from chair five times without support; (iii) poor energy. Cross-sectional and longitudinal associations of knee OA with prevalent and incident frailty, respectively, were examined using binomial regression with robust variance estimation, adjusting for potential confounders.
In the cross-sectional analyses, frailty was more prevalent among participants with ROA (4.39% vs 2.77%; PR 1.60 [1.07, 2.39]) and SOA (5.88% vs 2.79%; PR 1.92 [1. 35, 2.74]) compared with those without ROA or SOA, respectively. In the longitudinal analyses, risk of developing frailty was greater among those with ROA (4.73% vs 2.50%; RR 1.45 [0.91, 2.30]) and SOA (6.30% vs 2.83%; RR 1.66 [1.11, 2.48]) than those without ROA or SOA, respectively.
Knee OA is associated with greater prevalence and risk of developing frailty. Understanding the mechanisms linking these two common conditions of older adults would aid in identifying novel targets for treatment or prevention of frailty.
Details
- Title: Subtitle
- Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative
- Creators
- Devyani Misra - Department of Medicine, Boston University School of Medicine, Massachusetts. demisra@bu.eduDavid T Felson - Department of Medicine, Boston University School of Medicine, MassachusettsRebecca A Silliman - Department of Medicine, Boston University School of Medicine, MassachusettsMichael Nevitt - Department of Epidemiology and Biostatistics, University of California at San FranciscoCora E Lewis - Department of Medicine, University of Alabama School of Medicine, BirminghamJames Torner - Department of Epidemiology, University of IowaTuhina Neogi - Department of Medicine, Boston University School of Medicine, Massachusetts
- Resource Type
- Journal article
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.70(3), pp.339-344
- DOI
- 10.1093/gerona/glu102
- PMID
- 25063080
- PMCID
- PMC4351392
- NLM abbreviation
- J Gerontol A Biol Sci Med Sci
- ISSN
- 1079-5006
- eISSN
- 1758-535X
- Publisher
- United States
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS AR47785 (MRCR P60) / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01-AG18947 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS U01-AG18832 / NIA NIH HHS K23 AR055127 / NIAMS NIH HHS P30 DK079626 / NIDDK NIH HHS U01-AG19069 / NIA NIH HHS U01-AG18820 / NIA NIH HHS R01AR062506-01A1 / NIAMS NIH HHS R01 AR062506 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 03/2015
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995124702771
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